专业打印机暴露在甲酸盐中的荷尔蒙变化表明了潜在的下丘脑-垂体-腺轴的干扰
Tiberiu M Nita1, Sonja A Wrobel2, David Vernez1
1Unisanté, University Center for Primary Care and Public Health & University of Lausanne, Switzerland.
Environmental research
|December 5, 2025
概括
打印机中的职业甲酸盐暴露可能会破坏男性生殖荷尔蒙. 某些酸盐的水平升高与抗雄激素效应和潜在的荷尔蒙失衡有关,影响下丘脑 - 垂体 - 淋巴腺 (HPG) 轴.
科学领域:
- 职业健康 职业健康 职业健康
- 内分泌学 在内分泌学.
- 环境科学 环境科学
背景情况:
- 甲酸盐暴露是男性生殖健康问题的潜在危险因素.
- 人类对甲酸盐影响的证据有限且不一致.
- 职业环境提供了研究高水平暴露和开发干预措施的机会.
研究的目的:
- 研究职业甲酸盐暴露和打印机中的男性生殖激素之间的剂量反应关系.
- 为了检查一个工作周内的荷尔蒙变化和整体工作周的平均值.
- 评估尿甲酸代谢产物与特定生殖激素之间的关联.
主要方法:
- 对59台男性打印机进行生物监测,通过35种尿路代谢物评估18种甲酸盐.
- 对11种生殖激素的血液样本进行分析,包括的变体,SHBG,LH,FSH,益生菌素,雌激素和抑制素.
- 应用多重对共变量调整的线性回归来确定剂量反应关系.
主要成果:
- 在di-n-butyl甲酸盐 (DnBP) 代谢产物和计算自由 (cFT) 之间发现了负相关性.
- 在二乙-基甲酸盐 (DEHP) 代谢产物和性激素结合球蛋白 (SHBG) 之间存在正相关性.
- 观察到特定的甲酸盐代谢产物与抑制素B,FSH,生物可用的 (BioT) 和雌激素 (E2) 之间的关联,代谢产物水平高于一般人群的2至7倍.
结论:
- 打印机中的职业甲酸盐暴露与激素模式有关,这表明它具有抗雄激素作用.
- 这些发现表明男性下丘脑-垂体-淋巴结核 (HPG) 轴的潜在变化.
- 该研究强调了在高甲酸盐暴露的职业环境中需要风险降低策略的必要性.
相关概念视频
Gonadal and Placental Hormones
2.7K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
2.7K
Major Hormones and Their Functions
1.6K
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
1.6K
Hormonal Regulation
35.6K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
35.6K
Hormonal Regulation
47.7K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
47.7K
Hormonal Regulation of the Menstrual Cycle
1.4K
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
1.4K
Spermatogenesis
121.3K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
121.3K


