长期非药物干预后儿童的病原体特异性免疫债务:中国的一项横截面研究
Haibo Li1, Jing Liu2, Qianjiao Fang3
1National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, PR China; Department of Respiratory Medicine, Capital Medical University, Beijing, PR China; New Cornerstone Science Laboratory, Beijing, PR China.
在COVID-19期间长时间的非药物干预 (NPI) 在中国儿童中造成了免疫债务. 一些呼吸道病原体的抗体水平在NPI期间下降,然后反弹,表明敏感性增加.
科学领域:
- 儿童传染病 儿童传染病
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 在COVID-19大流行期间,非药物干预 (NPI) 减少了呼吸道病原体的循环.
- 在中国,长期NPI对儿童免疫力或"免疫债务"的影响尚不清楚.
研究的目的:
- 调查长期NPI后中国幼儿免疫债务的血清学证据.
- 分析针对10种常见的呼吸道病原体的病原体特异性抗体水平.
主要方法:
- 在北京对235名儿童 (9个月-5岁) 的横截面研究 (2021年11月-2023年10月).
- 使用新型抗原特异检测平台测量血清IgG抗体.
- 跨时期抗体水平的比较:在NPI期间,在NPI之后,以及在Mycoplasma pneumoniae流行期间;医院核酸监测数据 (2017-2023) 的分析.
主要成果:
- 抗 Mycoplasma pneumoniae 和 A 型流感的抗体标位在 NPI 期间下降,在 NPI 后反弹,与临床检测增加相关.
- 对B型流感,RSV,类流感病毒和腺病毒的抗体水平保持稳定.
- 在2022年12月之后,SARS-CoV-2抗体标位增加.
结论:
- 这项研究提供了第一个多病原体血清学证据,证明由于长时间的NPI,中国幼儿的免疫债务.
- 免疫债务对具有高流行前流行或快速抗原漂移的病原体最为显著.
- 持续的血清学监测和有针对性的疫苗接种对于管理NPI后流行病反弹至关重要.
更多相关视频
08:44Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
07:36Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection
Published on: February 28, 2021
相关概念视频
Immunodeficiency Diseases
There are three main causes of immunodeficiency...
Vaccinations
Immunological Memory
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
Infection
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
