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通过IL-17A介导的铜积累通过增强微质突触修剪来参与慢性神经病痛诱导的认知障碍

Jie Liu1, Zheng Li1, Xiaoling Peng1

  • 1Department of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 Hubei, China.

Brain, behavior, and immunity
|December 5, 2025
PubMed
概括

慢性神经病痛会通过激活微质来削减突触而导致认知障碍. 交叉蛋白-17A (IL-17A) 驱动铜的积累,导致突触损失和认知能力下降.

关键词:
慢性神经病变性疼痛 慢性神经病变性疼痛认知障碍 认知障碍是一种认知障碍.铜的积累 铜的积累它们的IL-17A是IL-17A.微质细胞中的微质细胞突触切割是指突触的切割.

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