循环和便微RNA作为IBD的非侵入性生物标志物:当前的证据和下一步
Vytautas Kiudelis1, Juozas Kupcinskas1, Alexander Link2
1Institute for Digestive Research and Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Best practice & research. Clinical gastroenterology
|December 5, 2025
概括
微RNAs作为炎症性肠道疾病 (IBD) 的非侵入性生物标志物具有前景. 需要进一步的研究来克服局限性,并将这些循环和便的microRNA开发成临床上有用的诊断工具.
科学领域:
- 生物标志物 生物标志物
- 分子生物学分子生物学
- 胃肠病学 胃肠病学
背景情况:
- 炎症性肠道疾病 (IBD) 的诊断依赖于侵入性方法,如内镜和组织学.
- 目前的非侵入性生物标志物,如便calprotectin和血液测试,在特异性和准确性方面存在局限性.
- 微RNAs (miRNAs) 正因为它们的稳定性和特定疾病的表达模式而成为潜在的非侵入性生物标志物.
研究的目的:
- 综合审查当前关于循环和便中的miRNAs作为IBD的非侵入性生物标志物的研究.
- 综合有关MIRNA在IBD的诊断和监测潜力的证据.
- 确定开发IBD基于miRNA的生物标志物的关键挑战和未来方向.
主要方法:
- 对研究IBD患者血液和便样本中的miRNA进行系统审查.
- 对方法方法的分析,以及在各种研究中报告的发现.
- 评估miRNAs在IBD诊断和疾病监测方面的潜力.
主要成果:
- 许多研究已经探索了循环和便中的miRNA用于IBD检测.
- 在研究方法,样本类型和分析技术方面存在显著的异质性.
- 有证据表明miRNAs具有潜力,但需要标准化才能用于临床应用.
结论:
- 微RNA代表了开发下一代IBD非侵入性生物标志物的有希望的途径.
- 解决方法异质性对于将miRNA研究转化为临床实践至关重要.
- 标准化协议和进一步验证是必要的,以建立可靠的miRNA生物标志物用于IBD管理.
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