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有口腔状细胞癌和没有口腔状细胞癌的患者口腔微生物群的差异

Satoshi Fukase¹, Atsumu Kouketsu¹, Toru Tamahara²

¹Division of Oral and Maxillofacial Oncology and Surgical Sciences, Department of Disease Management Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

|December 5, 2025

概括

口腔微生物群的变化与口腔状细胞癌 (OSCC) 的发展有关. 先进的OSCC病例显示出明显的细菌特征,其Actinomycetia减少,Spirochaetia和Proteobacteria增加,包括Treponema.

科学领域:

微生物学微生物学
在瘤学瘤学.
基因组学就是基因组学.

背景情况:

虽然致病微生物与口腔癌有关,但与口腔状细胞癌 (OSCC) 相关的细菌菌群中的特定变化仍未得到充分研究.
这项研究使用先进的元基因组学分析研究了口腔微生物群组成和OSCC之间的关联.

研究的目的:

调查口腔微生物群和口腔状细胞癌 (OSCC) 之间的关联.
为了确定不同于OSCC患者和健康对照者的特定细菌种群.
探索口腔微生物组变化与OSCC进展之间的关系.

主要方法:

从64名OSCC患者和50名健康对照人群收集了唾液样本.
提取了细菌基因组DNA,并使用Illumina MiSeq平台进行了测序.
用"微生物生态学的定量见解2" (QIIME 2) 和微生物组合差异的统计测试来分析元基因组数据.

主要成果:

在OSCC患者和对照人群之间观察到阿尔法多样性指数 (财富,Faith-PD,Shannon) 的显著差异.
贝塔多样性分析显示,在先进的OSCC病例 (T3/T4,N1+) 中,口腔微生物群有明显的集群.
在先进的OSCC中,Actinomycetia (例如Actinomyces,Rothia) 减少,而Spirochaetia和Proteobacteria (例如Treponema) 增加.

结论:

口腔微生物组合的变化与口腔状细胞癌 (OSCC) 有关.
特定的细菌变化可能在OSCC的发展和进展中发挥作用.
口腔微生物组分析有助于理解OSCC的病原性.

关键词:

转基因组学是指转基因组学.我们的微生物群.口腔中的瘤.这是唾液,唾液.

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