流行病的沉默的阴影:历史上经过急性后果
Christine M Miller1, Janna K Moen2, Akiko Iwasaki2
1Department of Pediatrics, Division of Infectious Diseases and Global Health, Yale University School of Medicine New Haven, CT, USA.
Trends in immunology
|December 5, 2025
概括
数以百万计的人经历了长期COVID (COVID-19的后急性后续),这种情况类似于其他病毒后出现的急性后感染综合征 (PAIS). 了解长期COVID的理解
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 神经学 神经学
背景情况:
- 在SARS-CoV-2大流行中,突出出现了后急性感染综合征 (PAIS),包括COVID-19 (长期COVID) 的后急性后续.
- 一个多世纪以来,在各种流行性感染 (如流感和Borrelia burgdorferi) 之后,已经记录了PAIS.
- 慢性疾病,如肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 往往与先前的传染性触发因素有关.
研究的目的:
- 解决有关PAIS的基础生物机制的关键知识差距.
- 系统地调查感染后持续的症状,特别是长期COVID.
- 利用先进的技术,更深入地了解慢性疾病中宿主-病原体相互作用.
主要方法:
- 对PAIS进行系统调查.
- 利用先进的技术和分析工具.
- 定义长期COVID的生物学.
主要成果:
- 多种病原体可以导致持续的,不太了解的症状.
- 感染和随后的慢性疾病之间存在反复的关联.
- 这项研究旨在定义长期COVID的生物学.
结论:
- 了解长期COVID可以为宿主-病原体相互作用提供更广泛的见解.
- 调查PAIS对于了解慢性疾病的机制至关重要.
- 先进的工具为研究这些条件提供了前所未有的机会.
相关概念视频
Stages of Infection
64.8K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.8K
Steps in Outbreak Investigation
470
In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
470
Introduction to Epidemiology
1.6K
Epidemiology, known as the cornerstone of public health, involves studying the distribution and determinants of health-related events in defined populations and applying these insights to control health issues. This is essential for understanding how diseases spread, identifying populations at greater risk, and implementing measures to control or prevent outbreaks. Epidemiology addresses not only infectious diseases but also non-communicable conditions like cancer and cardiovascular disease,...
1.6K
Pneumonia II: Pathophysiology
2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Infection
11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Pneumonia I: Introduction
702
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
702

