与第一季度接触局部抗真菌药物相关的重大先天性形风险:一项大型索赔数据库研究
Tadaharu Kunitoki1, Takamasa Sakai2, Tomofumi Ishikawa3
1Division of Clinical Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
在怀孕的第一季度,局部使用抗真菌药物,包括miconazole,oxiconazole和isoconazole,并没有增加日本婴儿重大先天性形 (MCMs) 的风险.
科学领域:
- 产科和妇科 产科和妇科
- 甲状腺学 甲状腺学
- 药理流行病学 药理流行病学
背景情况:
- Vulvovaginal candidasis 在孕妇中很常见,需要安全的治疗选择.
- 在日本,关于第一季度局部抗真菌药物的安全性和胎儿后果的数据有限.
- 评估重大先天性形 (MCMs) 的风险对于母亲和婴儿的健康至关重要.
研究的目的:
- 调查第一季度局部抗真菌使用与婴儿MCM风险之间的关联.
- 评估在日本早期怀孕期间使用米可纳,氧可纳和异可纳的安全性.
- 提供基于证据的指导,用于治疗怀孕妇女的 vulvovaginal candidasis.
主要方法:
- 在日本使用JMDC索赔数据库进行了嵌套妊娠队列研究.
- 包括在2010年至2019年间分娩的12,472名妇女,被诊断患有 vulvovaginal 候群性病.
- 在局部抗真菌药物 (miconazole,oxiconazole,isoconazole) 和clotrimazole (参考) 之间使用倾向性得分重叠权重进行了MCM风险的比较.
主要成果:
- 总体上,MCM的患病率在暴露的妇女中为5.8%,未暴露的妇女中为6.2%.
- 与克洛特里马相比,没有观察到oxiconazole (wOR 0.875),isoconazole (wOR 1.001) 或miconazole (wOR 0.887) 的MCM风险增加.
- 结果表明,这些局部抗真菌药在怀孕早期具有有利的安全性.
结论:
- 在怀孕第一季度局部使用抗真菌药物与婴儿患MCM的风险增加没有显著关联.
- 这些发现支持使用miconazole,oxiconazole和isoconazole在怀孕早期治疗vulvovaginal candidiasis.
- 进一步的研究可以在不同人群中加强这些安全发现.
更多相关视频
08:54Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
Published on: February 14, 2018
08:50A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
相关概念视频
Teratogenicity
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Fungal Phylum Microsporidia
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
