相关实验视频

Updated: Jan 9, 2026

Measurements of Physiological Stress Responses in C. Elegans

Measurements of Physiological Stress Responses in C. Elegans

Published on: May 21, 2020

在ER压力和脂质代谢之间的双向交叉:从蛋白质稳定到瘤适应

Yueling Wu¹, Huijuan Luo^2,3, Zhiwei Pan²

¹Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, 999078, China.

Cell death discovery

|December 5, 2025

概括

癌细胞通过将内质网膜 (ER) 压力和脂质代谢联系起来,适应压力. 本综述探讨了这种蛋白质稳定驱动网络如何影响瘤存活率,并讨论了向疗法.

科学领域:

在瘤学瘤学.
细胞生物学细胞生物学
代谢过程中的代谢.

背景情况:

细胞内膜网膜 (ER) 应激是一种关键的适应性反应,在各种挑战下维持蛋白质稳定.
在癌症中,ER压力和脂质代谢是双向相关的,影响蛋白质质量控制和脂质重塑.
展开的蛋白质反应 (UPR) 重编程脂质通路,以支持癌细胞的能量和膜需求.

研究的目的:

审查ER压力和癌症中的脂质代谢之间的交叉关系.
要突出蛋白质稳定在瘤适应压力的作用.
总结针对这种适应性网络的治疗策略.

主要方法:

文献综述侧重于ER压力,脂质代谢和癌症中的蛋白质稳定.
对集成UPR,脂质通路和蛋白质降解系统 (UPS,自) 的监管网络的分析.
针对这种适应轴的新兴治疗方法的摘要.

主要成果:

在癌症中,ER压力和脂质代谢形成了一个紧密结合的双向调节网络.
这个网络通过将蛋白质质量控制与脂质重塑相结合来维持瘤的生存.
不调节的脂质积累放大了ER压力,创建了对恒常状态有害但对瘤适应有益的反循环.
蛋白质稳定系统 (UPS,自) 与UPR合作,在压力下提高瘤存活率.

结论:

癌细胞应激和脂质代谢之间的相互作用对于癌细胞的适应和生存至关重要.
针对这种蛋白质稳定驱动的适应性网络提供了有前途的治疗策略.
新兴疗法包括小分子,天然产品和组合治疗来克服药物耐药性.

更多相关视频

Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons

Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons

Published on: April 24, 2021

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Published on: January 31, 2025

相关概念视频

Role of ER in the Secretory Pathway

Role of ER in the Secretory Pathway

Eukaryotic cells have a special pathway that enables communication between various intracellular membrane-bound compartments and also with the extracellular environment. This pathway is termed as the secretory pathway.
Components of the secretory pathway
About a third of proteins synthesized in the cell are sorted via the secretory route. They shuffle between different compartments in membrane-bound vesicles until they reach their final destination. The main intracellular compartments involved...

Regulation of the Unfolded Protein Response

Regulation of the Unfolded Protein Response

Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...

The Unfolded Protein Response

The Unfolded Protein Response

The ER is the hub of protein synthesis in a cell. It has robust systems to quality control protein folding and also for degradation of terminally misfolded proteins. Under normal conditions, a small proportion of misfolded proteins that cannot be salvaged need to be transported to the cytoplasm by the ER-associated degradation or ERAD pathways. However, if the ERAD cannot handle the misfolded proteins, the cell activates the unfolded protein response or UPR to adjust the protein folding...

Interactions Between Signaling Pathways

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...

Export of Misfolded Proteins out of the ER

Export of Misfolded Proteins out of the ER

After folding, the ER assesses the quality of secretory and membrane proteins. The correctly folded proteins are cleared by the calnexin cycle for transport to their final destination, while misfolded proteins are held back in the ER lumen. The ER chaperones attempt to unfold and refold the misfolded proteins but sometimes fail to achieve the correct native conformation. Such terminally misfolded proteins are then exported to the cytosol by ER-associated degradation or ERAD pathway for...

Assembly of the Lipid Bilayer in the ER

Assembly of the Lipid Bilayer in the ER

Biological membranes are more than just a barrier separating cell cytoplasm from the outside environment. They are highly dynamic and help maintain the integrity and physiological stability of the cells as well as membrane-bound organelles. Membranes also play vital roles in cell-to-cell and intracellular communication.
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...