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Updated: Jan 9, 2026

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
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Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients

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环保 AQbD 指导的稳定性指示 RP-UPLC 方法用于分析散装和剂量形式的托沃法尼布

Vanga Mohan Goud1, Sarad Pawar Naik Bukke2, Praveen Kumar Kusuma3

  • 1Department of Pharmaceutical Analysis, Joginpally BR Pharmacy College, Telangana, 500075, Hyderabad, India.

Scientific reports
|December 5, 2025
PubMed
概括

一种新的,环保的液态色谱法量化了Tovorafenib,这是一种治疗儿科低度质瘤的重要药物. 这种经过验证的方法可确保准确的药物分析,用于质量控制和环境可持续性.

关键词:
设计中的分析质量 (AQbD)绿色分析化学 绿色分析化学快速的RGB快速的RGB快速的在 RP-UPLC 中.托沃法尼比的使用方法

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Improved UPLC-UV Method for the Quantification of Vitamin C in Lettuce Varieties Lactuca sativa L. and Crop Wild Relatives Lactuca spp.10:22

Improved UPLC-UV Method for the Quantification of Vitamin C in Lettuce Varieties Lactuca sativa L. and Crop Wild Relatives Lactuca spp.

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Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
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Pharmacokinetics is a vital branch of pharmacology that examines how drugs are absorbed, distributed, metabolized, and excreted by the body. Two key methodologies in pharmacokinetics are plasma drug concentration studies and urinary drug excretion analyses, both of which provide critical insights into a drug's therapeutic efficacy and bioavailability.Plasma Drug Concentration-Time StudiesPlasma drug concentration-time studies involve analyzing blood samples at specific intervals to quantify...
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