预测因子和免疫炎症指数的预测性表现,用于良性前列腺增生症的症状严重程度
Altaseb Beyene Kassaw1, Said Mohammed Abdu2, Gashaw Abebe2
1Department of Biomedical Science, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia. altasebbeyene7@gmail.com.
Scientific reports
|December 5, 2025
概括
高龄,体力活动低,中心肥胖和SII和PII等免疫炎症标志物升高是严重良性前列腺增生症 (BPH) 症状的显著预测因素. SII和PII具有中等的预测价值,可以作为BPH严重程度的可访问生物标志物.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 炎症研究 炎症研究
- 生物标志物发现发现
背景情况:
- 良性前列腺增生症 (BPH) 是一个常见的疾病,受年龄和遗传学的影响,但可改变的因素也会影响其进展和症状严重程度.
- 确定BPH症状严重程度的预测因素和客观生物标志物对于有效的患者管理至关重要.
研究的目的:
- 为了确定BPH症状严重程度的预测因素.
- 评估血液学衍生炎症标志物对埃塞俄比亚患者BPH严重性的预测性表现.
主要方法:
- 一项涉及埃塞俄比亚德西综合专门医院232名BPH患者的横截面研究.
- 通过面对面采访收集的数据;使用STATA进行统计分析,包括后勤回归和ROC曲线分析.
- 对SII,PII,NLR,PLR和LMR等免疫炎症指数的评估,以预测性能.
主要成果:
- 年龄≥65岁,体力活动低,中心肥胖,SII,PII和NLR升高与严重BPH症状显著相关 (p <0.05).
- SII (AUC=0.736) 和PII (AUC=0.729) 显示严重BPH的预测性能中等,而SII显示出更高的分辨准确性.
- SII显示出非线性,与严重BPH概率的积极关联,在更高水平时风险增加.
结论:
- 高龄,不良的生活方式因素和系统性炎症标志物 (SII,PII,NLR) 的升高是BPH严重程度的重要预测因素.
- 从常规血液测试中得出的SII和PII显示出潜在的可访问,非侵入性的辅助生物标志物,用于识别严重的BPH.
- 建议进行进一步的研究来验证这些发现,并探索它们在治疗决策中的临床影响.
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