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Barbora Riesova¹, Lorena Agostini Maia², Renata Hesova¹

¹Department of Animal Protection and Welfare & Veterinary Public Health, University of Veterinary Sciences, Brno, Czech Republic.

Scientific reports

|December 5, 2025

概括

可纳及其核心结构通过改变关键的Wnt和BMP信号通路来破坏两动物的发育. 这些发现凸显了醇化合物暴露对水生脊椎动物的潜在风险.

科学领域:

环境毒理学环境毒理学
发育生物学是发展生物学.
分子毒理学分子毒理学

背景情况:

可纳 (FLU) 是一种常见的抗真菌药物,由于广泛使用,在地表水中检测到.
它的环境持久性和发育毒性令人担忧,但对两动物的影响尚不清楚.

研究的目的:

研究FLU及其核心1,2,4-triazole (TRI) 对两动物胚胎的发育和分子影响.
评估基因表达和发育表型的变化.

主要方法:

在Xenopus laevis胚胎中,FLU或TRI的度不同.
评估的终点包括死亡率,化率,心率,身体长度,形和基因表达分析.

主要成果:

FLU和TRI都在低微分子水平上改变了Wnt和BMP相关的基因表达.
较高度导致发育异常,如头部尺寸缩小,颜色变化和消化道形.
现型变化与分子通路中断相关.

结论:

单独的三醇核心 (TRI) 可以破坏脊椎动物胚胎中关键的发育信号通路.
结果表明醇暴露在水生脊椎动物中的潜在风险,需要环境监测.
在环境和临床环境中,人们对长期或产前暴露的风险表示担忧.

关键词:

亚醇抗真菌剂是一种抗真菌剂.胚胎毒性胚胎毒性基因表达基因表达基因表达形态测量分析分析的方法非目标水生脊椎动物在Wnt/BMP信号传输中.

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