交叉链接和非交叉链接的原异质移植的比较,用于子calvaria的垂直骨增强
Hee-Seung Han1, Hyunkyung Kim2, Narasaem Lee3
1Department of Periodontology, Korea University Anam Hospital, Seoul, Republic of Korea.
Scientific reports
|December 5, 2025
概括
与脱蛋白牛骨矿物质 (DBBM-Cb) 交联的牛原蛋白在子模型中显示出优异的骨再生和体积稳定性,与非交联的猪原蛋白相比. 这种原蛋白骨移植材料增强了垂直骨增强的结果.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 口腔和牙面部外科手术
背景情况:
- 牛和猪的异种移植具有骨传导性,广泛用于骨增强.
- 添加原蛋白可以改善骨移植的处理和完整性.
- 交叉连接的原蛋白增强了骨质移植中的骨质生成潜力和结构稳定性.
研究的目的:
- 为了比较两个原异质移植的骨质导电性和体积稳定性,用于垂直骨增强.
- 评估用交叉连接的牛原蛋白 (DBBM-Cb) 与非交叉连接的猪原蛋白 (DBBM-NCp) 的脱蛋白牛骨矿物质.
- 为了评估子形模型中的组织学变化.
主要方法:
- 使用子形模型用于垂直增强和关键尺寸缺陷.
- 分析了使用场辐射扫描电子显微镜的移植表面形态.
- 通过微计算机断层扫描和在多个时间点 (3,5,6和12周) 的组织学分析评估体内骨再生.
主要成果:
- 两种移植都表现出多孔,相互连接的微型架构,有利于骨质传导.
- 在增强模型中,DBBM-Cb在3周时显示出明显更高的骨体积分数,并在3周和5周时保持垂直身高.
- 在缺陷模型中,DBBM-Cb在12周后导致缺陷关闭显著增加,并改善了移植集成和骨成熟.
结论:
- 与DBBM-NCp相比,DBBM-Cb表现出优越的骨质导电性,结构稳定性和移植体积的维持.
- 交叉连接的牛原蛋白骨移植在垂直骨增强中表现更好.
- DBBM-Cb显示出作为一个更有效的生物材料的潜力,用于垂直骨增强程序.
更多相关视频
09:09Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
Published on: March 14, 2019
9.4K
08:41Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
8.8K
相关概念视频
Bone Structure
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone as Supporting Connective Tissue
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Bones of the Lower Limb: Tibia and Fibula
The tibia is the main weight-bearing bone of the lower leg. It is larger than the fibula with which it is paired. The tibia is also the second longest bone in the body and is located right below the skin. The proximal end of the tibia forms the medial and the lateral condyle, which articulates with the condyles of the femur to form the knee joint. Between the articulating surfaces is the irregular elevated area known as the intercondylar eminence that serves as the inferior attachment point for...
Bone Remodeling and Repair
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Structural Joints: Cartilaginous Joints
As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary or...
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary or...
