肠道基因表达在微生物群的基因调节有助于人类疾病的遗传性
Haochuan Wang1,2,3, Chengyu Li1,2, Zhen Hu4
1The Second Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, 311121, Hangzhou, China.
Molecular systems biology
|December 5, 2025
概括
这项研究绘制了肠道微生物群的宿主基因调节图,揭示了微生物活动,宿主遗传和抑郁症和过敏等疾病之间的联系. 这些发现为了解微生物组依赖的健康和疾病创造了一个框架.
科学领域:
- 基因组学就是基因组学.
- 微生物学 微生物学
- 系统生物学 系统生物学
背景情况:
- 肠道微生物组在健康和疾病中的作用是显著的,但其与宿主基因表达的相互作用尚未完全理解.
- 了解宿主微生物群相互作用对于剖析疾病机制至关重要.
研究的目的:
- 将微生物属的遗传调节图与宿主基因表达定量特征定位点 (eQTLs) 和DNA甲基化定量特征定位点 (mQTLs) 整合起来.
- 在不同的肠道组织中识别基因到微生物组的调节位置.
- 探索宿主微生物群相互作用与疾病易感性之间的联系.
主要方法:
- 整合了来自116个微生物属的遗传调节图,并将来自三个肠道组织的eQTL和mQTL数据整合在一起.
- 对基因到微生物组调节位置的分析.
- 整合性分析与全基因组关联研究 (GWASs).
- 预测宿主-微生物组-疾病联系的实验验证.
主要成果:
- 识别了成千上万的基因与微生物组调节位点在横向结肠,西格结肠和大肠.
- 发现13.2%的基因对多个属具有广泛的调节效应,丰富了发育,代谢和免疫路径.
- 通过GWAS整合,揭示了283个微生物组依赖的疾病基因,突出显示了类效应.
- 在抑郁症 (Allisonella) 和过敏性鼻炎 (Parasutterella) 中特定微生物作用的实验验证.
结论:
- 建立了全面的基因-微生物组-疾病监管地图.
- 证明了宿主基因调节对肠道微生物群及其对疾病的贡献的重大影响.
- 为进一步研究宿主-微生物组-疾病相互作用提供了一个有价值的互动数据库.
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