急性髓性白血病的全球流行病学
Firas El Chaer1, Jan P Bewersdorf2,3, Maximilian Stahl2,3
1Department of Hematology, Miami Cancer Institute, Baptist Health, South Florida, Miami, FL, USA.
Nature reviews. Clinical oncology
|December 5, 2025
概括
急性髓性白血病 (AML) 的发病率和结果在全球范围内各不相同. 治疗方面的进步有利于高收入国家,而低收入国家面临差距,突出需要改善监督和公平获取.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 急性髓性白血病 (AML) 是一种侵袭性癌症,发病率随着年龄的增长而上升.
- 全球AML发病率,风险因素和结果显示出显著的区域差异.
- 在AML治疗和结果方面的进展主要集中在高收入国家.
研究的目的:
- 审查AML发病率,风险因素和人口差异的全球趋势.
- 分析不同地理区域的AML患者的治疗相关结果.
- 确定全球AML监测和患者护理需要改进的领域.
主要方法:
- 全球流行病学数据对急性髓性白血病的审查.
- 对AML发病率和结果的人口差异的分析.
- 评估不同经济地区的治疗机会和结果.
主要成果:
- 随着年龄的增长,AML的发病率会增加,并且因风险因素和医疗保健准入而因地区而异.
- 高收入国家由于新的治疗方法和更好的护理, AML 结果有所改善.
- 低收入和中等收入国家面临更高的AML死亡率和发病率,治疗选择有限.
结论:
- 在AML发病率,风险因素和治疗结果方面存在显著的全球差异.
- 癌症登记,全球监测,公平获得护理和临床试验等方面迫切需要改进.
- 利用人工智能进行数据分析可以帮助应对反洗钱挑战.
更多相关视频
09:57Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
Published on: March 5, 2018
30.3K
09:01Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
14.6K
相关概念视频
01:27Disorders of Leukocytes
1.8K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
1.8K
01:15Differentiation of Common Myeloid Progenitor Cells
3.9K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.9K