脑活动和与孤独相关的功能连接模式:休息状态fMRI研究
Fenghua Zhang1, Jin Yang2, Xiaoqiang Yao3
1School of Psychology, Jiangxi Normal University, No. 99, Ziyang Avenue, Nanchang, 330022, China.
Cognitive, affective & behavioral neuroscience
|December 5, 2025
概括
孤独与前后部大脑活动的改变以及特定的功能连接模式有关. 了解这些神经相关性是开发有效干预措施的关键,以解决这个日益严重的公共卫生问题.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 公共卫生 公共卫生
背景情况:
- 孤独是一个日益严重的公共卫生问题,与不良的心理和身体健康结果有关.
- 城市化和人口老龄化加剧了孤独感,需要对它的神经支进行研究.
- 了解孤独的大脑机制对于开发有针对性的干预措施至关重要.
研究的目的:
- 为了研究年轻成年人孤独的神经相关性.
- 确定与主观孤独感相关的特定大脑区域和网络.
主要方法:
- 休息状态功能磁共振成像 (fMRI) 数据从238名年轻成年人 (年龄17-26岁) 中收集.
- 低频波动的分数振幅 (fALFF) 和功能连接 (FC) 分析被使用.
- 进行了统计相关性,以将孤独得分与大脑活动和连接性联系起来.
主要成果:
- 孤独与右后前骨中的fALFF负相关,表明大脑内在活动发生变化.
- 在与孤独相关的右后前和右上额前之间发现了积极的FC.
- 在右腹中前额叶皮层和包括小脑,状回环和上回环在内的网络之间观察到负FC.
结论:
- 后部前骨内在活动的明显模式与孤独有关.
- 涉及社会认知和情绪调节网络的特定功能连接性改变与孤独有关.
- 这些发现为孤独的个体差异提供了神经证据,并告知了潜在的神经刺激和认知行为干预措施.
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