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Elzem Nisa Alkan¹, Neslihan Hekim¹, Sezgin Gunes^2,3

¹Department of Medical Biology, Faculty of Medicine, Ondokuz Mayis University, Samsun, 55139, Turkey.

Basic and clinical andrology

|December 5, 2025

概括

分析了肥胖男性的精液微生物群组成. 发现特定的细菌系与男性不孕症标志物 (如精子DNA碎片化和减少抗氧化能力) 相相关.

科学领域:

微生物学微生物学
生殖医学生殖医学
安德罗学与人类学

背景情况:

肥胖是影响男性生殖健康的日益严重的问题.
精子微生物群在肥胖男性不孕症中的作用需要进一步研究.

研究的目的:

评估肥胖男性精液中的微生物含量和多样性.
为了比较不孕不育和肥胖的肥胖男性.
确定精液微生物群对精液参数的影响,精子DNA碎片化,染色质凝聚和总抗氧化能力.

主要方法:

来自不育和肥胖男性 (BMI > 30 kg/m2) 的精液样本的分析.
使用16S rRNA测序识别细菌类和属的鉴定.
细菌属和精液质量参数,精子DNA碎片化和总抗氧化能力之间的相关性分析.

主要成果:

最丰富的细菌系是Bacillota,Pseudomonadota,Actinomycetota和Bacteroidota. 这些细菌系中,最丰富的细菌系是Bacillota,Pseudomonadota,Actinomycetota和Bacteroidota.
常见的属包括Pseudescherichia,Staphylococcus,Paenibacillus和Streptococcus,在两个群体中分布相似.
与精子DNA碎片化 (Brevibacterium,Paenibacillus),总抗氧化能力 (Pantoea,Devosia),素丰富的精子 (Fusobacterium) 和BMI (Corynebacterium,Hydrogenophaga) 相相关的特定属.

结论:

精液中的细菌物种可能会影响男性不孕.
在肥胖男性中,精液微生物群可以影响精液质量,精子DNA碎片化和总抗氧化能力.

关键词:

男人不孕不育的情况微生物组是一个微生物组.肥胖问题肥胖问题精子DNA碎片化精子DNA碎片化精子染色素凝结的凝结方式总的抗氧化能力.

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