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相关概念视频

Circadian Rhythms and Gene Regulation02:19

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
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The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
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相关实验视频

Updated: Jan 9, 2026

A User-friendly and Powerful R Analysis of Large-scale Datasets
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easyClock:一个用户友好的桌面应用程序,用于昼夜节律分析和可视化.

Binbin Wu1, William W Ja2

  • 1Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL, 33458, USA. binbin.wu@ufl.edu.

BMC bioinformatics
|December 5, 2025
PubMed
概括

easyClock通过一个直观的开源应用程序简化了昼夜节律分析. 该工具允许批处理,可视化和时间序列数据的统计评估,而不需要编程技能.

关键词:
循环节律是指循环节律的节奏.非编码的分析工具.这是开源的,开源的.节奏检测检测器 节奏检测器视觉化的可视化

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科学领域:

  • 时间生物学 时间生物学
  • 生物信息学是一种生物信息学.
  • 数据科学数据科学数据科学

背景情况:

  • 昼夜节律控制着许多生物过程,需要准确的分析来理解生理和行为模式.
  • 当前的昼夜数据分析工具往往需要编程技能或专有软件,这阻碍了广泛采用.
  • 需要可访问,用户友好的软件来分析复杂的昼夜时间序列数据.

研究的目的:

  • 介绍easyClock,一种直观和交互式的应用程序,用于简化昼夜节律分析和可视化.
  • 提供一种多功能工具,能够处理各种时间序列数据集,包括具有不同波形和噪声的数据集.
  • 为了促进研究人员对昼夜数据的有效批处理和统计评估.

主要方法:

  • 开发一个名为easyClock的交互式图形用户界面 (GUI) 应用程序.
  • 实施批处理能力,用于同时分析多个数据文件.
  • 统计方法的整合,包括线性混合效应建模,用于评估个人间的变化和群体差异.
  • 支持数据可视化和输出结果和图表.

主要成果:

  • easyClock 能够同时对多个昼夜时间序列数据集进行批量分析和可视化.
  • 该应用程序有效地处理各种波形和噪声水平的数据,确保可靠的分析.
  • 通过集成的统计建模,easyClock 便于评估个体间的变化和群体差异.
  • 通过对时间序列转录组数据集的重新分析来证明实用性.

结论:

  • easyClock是一个可访问的,开源工具,使昼夜节律分析民主化.
  • 该应用程序不需要编程专业知识,并为Windows和macOS上的研究人员提供了用户友好的体验.
  • 简单的时钟在昼夜数据分析和可视化方面提高了效率和可比性.