男性和女性的生物衰老和寿命使用孟德尔的随机化研究
C M Schooling1,2, Shun Li3, Zhu Liduzi Jiesisibieke4
1Graduate School of Public Health and Health Policy, The City University of New York, 55 West 125th St, New York, NY, 10027, USA. mary.schooling@sph.cuny.edu.
Human genomics
|December 5, 2025
概括
端粒长度和表观遗传时钟不是提高男性或女性寿命的有效目标. 未来的衰老干预措施应该关注寿命的根本原因,而不是这些生物标志物.
科学领域:
- 遗传学和衰老研究研究
- 公共卫生生物标志物 公共卫生生物标志物
- 长寿研究 长寿研究
背景情况:
- 寿命是一个关键的公共卫生指标,需要确定干预目标.
- 端粒长度和表观遗传钟是关键的衰老生物标志物,但它们在寿命干预中的作用尚不确定.
- 研究这些生物标志物与寿命的性别相关性至关重要.
研究的目的:
- 为了确定端粒长度和表观遗传钟是否适合作为旨在促进人类寿命的干预的目标.
- 通过使用孟德尔随机化来检查端粒长度,表观遗传钟和寿命之间的性别特定因果关系.
主要方法:
- 利用来自英国生物银行 (N≈50万) 的端粒长度和寿命的遗传总结统计数据.
- 包括28个队列元分析 (N=34,710) 的表观遗传时钟数据 (GrimAge,PhenoAge,HannumAge,内在表观遗传年龄加速).
- 采用双样本的孟德尔随机化与逆方差加权和灵敏度分析来估计男性和女性的因果影响.
主要成果:
- 在男性或女性的端粒长度和寿命之间没有发现显著的关联.
- 端粒长度与女性更差的生存率与招募相关.
- 表观遗传时钟没有显示出与任何性别的寿命或生存的显著关联.
结论:
- 端粒长度和常见的表观遗传钟不太可能是延长寿命干预的有效目标.
- 未来的研究应该专注于确定和准寿命的基本因果驱动因素.
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