在食道内镜下粘膜剖析后对电凝综合征的抗生素预防:单一中心回顾性研究
1Department of Gastroenterology, The First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China.
Surgical endoscopy
|December 5, 2025
概括
抗生素预防 (AP) 在食道手术中没有显著降低后内镜下粘膜剖析 (ESD) 电凝综合征 (PEECS) 的发生率. 肌肉层损伤被确定为PEECS的危险因素.
科学领域:
- 胃肠病学 胃肠病学
- 内镜检查是指内镜检查.
- 外科手术的结果
背景情况:
- 内镜下粘膜切割 (ESD) 是表面食道病变的标准治疗方法.
- 后ESD电凝综合征 (PEECS) 是食道ESD后的一个常见并发症.
- 抗生素预防预防PEECS的有效性尚未得到充分证实.
研究的目的:
- 评估抗生素预防 (AP) 的有效性,以减轻患有食道ESD的患者中PEECS的发生.
- 为了比较接受AP和不接受AP的患者之间的PEECS发病率.
主要方法:
- 连续接受食道ESD的患者的回顾性分析.
- 倾向性得分 (PS) 匹配,以平衡AP和非AP组之间的基线特征.
- 评估PEECS,发烧,胸痛,实验室参数和住院时间.
主要成果:
- 在PS匹配后,分析了262名患者;PEECS发生率为AP的26.7%,而非AP的30.5% (P=0.494).
- 两组之间没有观察到PEECS发病率的统计学上显著差异.
- 消化道肌层损伤被确定为PEECS的重要危险因素 (OR 1.986,P=0.018).
结论:
- 抗生素预防似乎没有减少食道ESD后PEECS的发生率.
- 可能需要进一步的研究来探索PEECS预防的替代策略.
- 识别和管理肌肉层损伤等风险因素可能对PEECS管理至关重要.
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