循环节律障碍相关的功能障碍因衰老而加剧,因时间限制的养而改善
Fengjiao Huo1, Qing Liu1, Shuaishuai Zhang1
1Institute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200123, China.
Neuroscience bulletin
|December 5, 2025
概括
衰老和昼夜节律障碍 (CRD) 恶化了肠道健康和认知功能. 时间限制养 (TRF) 通过恢复肠道微生物和减少炎症,改善了老鼠的这些问题.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 时间生物学 时间生物学
背景情况:
- 昼夜节律是跨物种存在的基本生物过程.
- 循环节律障碍 (CRD) 影响所有年龄组,特别是那些患有神经退行性疾病的人.
- 肠道微生物群表现出自己的昼夜节律,越来越多地与神经健康和衰老有关.
研究的目的:
- 为了研究衰老,CRD和肠道微生物组之间的复杂关系.
- 探索CRD如何加剧与年龄相关的认知和情绪障碍.
- 评估时间限制养 (TRF) 在减轻老年人CRD影响方面的治疗潜力.
主要方法:
- 在老年小鼠中模拟CRD,使用受控的光/黑暗周期.
- 分析了肠道微生物组成,肠道屏障完整性和全身炎症.
- 评估了认知功能,情绪和昼夜基因表达.
- 评估了TRF对这些参数的影响.
主要成果:
- 患有CRD的老年小鼠表现出严重的认知和情绪缺陷,肠道失调,肠道屏障受损和全身炎症.
- 异常的昼夜基因表达与增加的氧化应激相关.
- 在老年小鼠中,TRF干预显著改善了CRD相关的结果.
- TRF促进了Akkermansia muciniphila的丰富性,并调节了NOD类信号通路.
结论:
- 衰老放大了CRD的负面影响,由肠道微生物引起的炎症和与昼夜基因相关的氧化应激驱动.
- 在衰老过程中,昼夜节律的扰乱和肠道失调有助于行为和功能衰退.
- 通过TRF建立定期的饮食模式,为缓解老龄人口中CRD引起的健康问题提供了一个有希望的策略.
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