神经症异质性通过项目级协会在静止状态的功能连接性异质性
Masaya Misaki1,2, Chun Chieh Fan3,4,5, Wesley K Thompson3,4,6
1Laureate Institute for Brain Research, Tulsa, OH, USA. mmisaki@laureateinstitute.org.
Communications biology
|December 5, 2025
概括
神经病症是一种神经病症.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 遗传学 是一个遗传学.
背景情况:
- 神经病症传统上被视为单一的特征,但越来越多地被认为是异质的.
- 这种异质性在遗传基础和对健康和社会结果的影响中很明显.
研究的目的:
- 通过静止状态功能连接 (RSFC) 来研究神经病症的神经功能异质性.
- 为了确定与个体神经病症方面相关的特定RSFC模式.
- 建立RSFC作为神经病症的潜在中间表型.
主要方法:
- 在一个大型的英国生物库数据集 (n=33,180) 中使用机器学习回归分析了RSFC.
- 相关联的RSFC模式与Eysenck人格调查问卷的项目级神经症得分.
- 在一个单独的英国生物银行MRI扫描时验证了这些发现.
主要成果:
- 确定了与神经病症方面相关的特定RSFC模式,与遗传集群 (焦虑,抑郁影响) 和心理测量因素 (焦虑/紧张,焦虑/脆弱) 相相关.
- 在一个独立的数据集中复制了这些神经功能特征.
- 主要在认知控制,感官集成和自我参考处理网络中观察到相关的连接性.
结论:
- 休息状态功能连接 (RSFC) 模式反映了神经病的异质性.
- RSFC作为一个强大的中间表型,将遗传倾向与心理状态联系起来.
- 这一框架可以改善对精神病脆弱性的预测,并指导个性化干预.
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