相关实验视频

Updated: Aug 13, 2026

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation
09:16

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation

Published on: June 26, 2018

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不同的微质对结构上不同的α-synuclein多态的反应

Katherine Chang1, Jina Kim2,3, Michiyo Iba1

  • 1Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.

Molecular brain
|December 6, 2025
PubMed
概括

在同核蛋白病变中,明显的α-synuclein聚合物会触发不同的微质神经炎症. 动力稳定的寡聚体和成熟的纤维素强烈激活微质反应,突出结构依赖的炎症性质.

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Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons

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Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions08:40

Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions

Published on: June 23, 2022

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相关概念视频

Protein Folding01:22

Protein Folding

Overview
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Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
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Amyloid Fibrils03:03

Amyloid Fibrils

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Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

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Amyloid Fibrils03:03

Amyloid Fibrils

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Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...