EnsembleAge时钟:一个可靠和强大的表观遗传年龄时钟服务揭示了阿片类药物过量使用的大脑中的表观遗传年龄加速
Akshay Anand1,2, Yash Agarwal1,3, Tanisha Gupta4
1Cancer Epigenetics Institute, Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
BMC genomics
|December 6, 2025
概括
我们开发了EnsembleAge,这是一种使用DNA甲基化来更准确地估计生物年龄的新方法. 它减少了与以前方法的差异,在阿片类药物过量服用的大脑中显示了显著的衰老加速,并提供了健康衰老的工具.
科学领域:
- 表观遗传学和衰老研究.
- 计算生物学和生物信息学
- 分子流行病学分子流行病学
背景情况:
- 年代年龄是个体健康状况的不良指标.
- DNA甲基化 (DNAm) 是与衰老相关的关键表观遗传标记物.
- 现有的基于DNAm的老化时钟由于训练数据而遭受高方差.
研究的目的:
- 为了开发更强大的基于DNA甲基化的衰老时钟,减少差异.
- 为了提高生物年龄估计的准确性.
- 在各种生物和临床环境中提供评估表观遗传年龄的工具.
主要方法:
- 集体学习方法结合了现有的八个DNAm时钟.
- 从九个器官 (GTEx数据集) 获得的DNA甲基化数据的训练模型.
- 对公共数据集的验证,包括阿片类药物使用和过量服用.
主要成果:
- 在全血中,EnsembleNaive时钟实现了4.04年的中位数绝对误差 (MeAE).
- 在多种组织中,EnsembleLR时钟实现了6.35年的MeAE.
- 在阿片类药物过量使用的大脑中发现了超过10年的年龄加速,而在使用时没有加速.
- 开发了一个用于生物年龄预测的网络服务.
结论:
- EnsembleAge 时钟提供了更强大,更准确的生物年龄估计.
- 这些模型在临床和法医应用中具有实用价值.
- EnsembleAge有助于追踪生物年龄,并促进健康的生活方式选择.
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