相关实验视频
Updated: Jan 9, 2026
08:40
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
7.5K
大规模的血蛋白学揭示了睡眠模式和炎症性肠道疾病之间的双向关联:一项前性队列研究
Kaixing Le1,2, Yaru Liu1,2, Rongpan Bai3
1National Clinical Research Center for Child Health, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China.
BMC medicine
|December 6, 2025
概括
不健康的睡眠与炎症性肠病 (IBD) 有关,增加了其流行和发病率. 炎症和代谢途径调解了这种联系,这表明睡眠评估对IBD管理至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 睡眠医学 睡眠医学
- 蛋白质组学是指蛋白质组学.
背景情况:
- 睡眠障碍在炎症性肠病 (IBD) 患者中很普遍,并且可以加剧疾病的进展.
- 这项研究研究了睡眠不足和IBD之间的双向关系,探索了潜在的蛋白质组机制.
研究的目的:
- 检查不健康的睡眠模式与IBD的流行率和发病率之间的联系.
- 为了识别介导不健康的睡眠和IBD之间的联系的蛋白质特征和途径.
- 根据蛋白质组数据开发IBD发病的预测模型.
主要方法:
- 分析英国生物库数据 (n=381,228) 以评估患有IBD的几率比率 (ORs) 和与睡眠模式相关的IBD事件的危险比率 (HRs).
- 使用差异表达分析和加权基因共同表达网络分析 (WGCNA) 的等离子体蛋白质组分析 (n=40,392).
- 使用LASSO-Cox回归来开发IBD的预后风险模型.
主要成果:
- 不健康的睡眠与更高的IBD流行率 (OR=1.250) 和发生IBD的风险增加 (HR=1.237) 有关.
- 确定了182种不同表达的蛋白质,这些蛋白质与不健康的睡眠和IBD共同存在,富含炎症和代谢途径.
- 一个蛋白质基因风险模型预测IBD发病的发生,AUC为0.81.1. 不健康的睡眠和高蛋白质基因风险相结合显著增加了IBD发病风险 (HR=3.370).
结论:
- 不健康的睡眠和IBD之间存在双向联系,由炎症和代谢过程介导.
- 蛋白质基因分析揭示了IBD的潜在生物标志物和治疗点.
- 建议将睡眠评估纳入IBD管理策略.
相关概念视频
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
617
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
617
01:30Inflammatory Bowel Disease II: Crohn's Disease
925
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
925
01:17Chronic Bowel Disorders: Introduction
734
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
734
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
862
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
862