在医疗辅助生殖后的父亲患产后抑郁症:基于登记的队列研究
Mette Bliddal1,2,3, Trine Munk-Olsen4, Xiaoqin Liu5
1Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Paediatric and perinatal epidemiology
|December 6, 2025
概括
通过医疗辅助生殖 (MAR) 怀孕的孩子的父亲有更高的患父亲产后抑郁症 (PPD) 的风险. 这项研究强调了需要增加对使用MAR的父亲的认识和支持.
科学领域:
- 生殖健康 生殖健康
- 心理健康 心理健康
- 父亲心理学 父亲心理学
背景情况:
- 医疗辅助生殖 (MAR) 与不利的心理健康结果有关.
- 对MAR和父亲产后抑郁症 (PPD) 的研究是有限的.
- 在MAR怀孕后,需要对父亲的PPD风险进行调查.
研究的目的:
- 调查MAR怀孕与父亲PPD风险之间的关联.
- 为了比较MAR怀孕孩子的父亲和无助怀孕的父亲的PPD病例.
- 为了确定与增加PPD风险相关的特定MAR因素.
主要方法:
- 全国丹麦卫生登记册 (2010-2019) 分析了新生儿的父亲.
- 儿童被归类为无助或MAR怀孕,并记录了MAR细节.
- 在产后12个月内通过医院诊断或抗抑郁药物处方确定PPD.
- 调整后的波桑回归分析考虑了共变量和聚类.
主要成果:
- 研究包括413,682名分娩;7.5%通过MAR怀孕.
- 马尔的父亲比较年长,更常见的是第一次父母,具有更高的社会经济地位.
- 在这两组中,PPD发生在0.9%的父亲身上.
- 马尔怀孕与22%的PPD风险增加有关 (aRR为1.22,95%CI为1.07-1.38).
- 在MAR类型中持续存在高风险,持续时间超过12个月的风险最高 (aRR 1.42).
结论:
- 通过MAR怀孕的父亲面临着明显增加的父亲产后抑郁症的风险.
- 调查结果强调需要提高认识和有针对性的父亲支持.
- 早期的育儿支持应考虑使用MAR的父亲所面临的独特挑战.
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