体重不足和2型糖尿病的死亡率:全国性的回顾性队列研究
Hun Jee Choe1, Kyong Do Han2, Ji-Hong Park3
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hallym University School of Medicine, Hwaseong, Republic of Korea.
Journal of cachexia, sarcopenia and muscle
|December 6, 2025
概括
体重不足状况显著增加了2型糖尿病 (T2D) 患者的死亡风险. 在这个人群中,严重体重不足比严重肥胖带来更大的死亡风险.
科学领域:
- 内分泌学和新陈代谢学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 体重不足是2型糖尿病 (T2D) 中未被认可的死亡风险因素.
- 这项研究调查了T2D患者体重不足和死亡率之间的联系.
研究的目的:
- 评估体重不足与T2D成年人全因和因特定死亡率的关联.
- 为了比较体重不足和严重肥胖的2型糖尿病患者之间的死亡风险.
主要方法:
- 全国范围,回顾性,基于人口的队列研究,使用韩国国家医疗保险服务数据.
- 包括2015-2016年期间查的1,788,996名患有T2D的成年人,随访至2022年.
- 体重不足定义为BMI<18.5公斤/平方米,分为轻度,中度和严重. 使用考克斯回归分析的全因死亡率.
主要成果:
- 在所有体重不足类别 (轻度,中度,重度) 中,观察到全因死亡率逐步增加.
- 严重体重不足 (BMI < 16.0 kg/m2) 的死亡风险高于严重肥胖 (BMI ≥ 35.0 kg/m2) 的死亡风险.
- 在体重不足类别中,与糖尿病相关的,心血管和脑血管死亡率的风险增加.
结论:
- 体重不足与T2D患者的死亡风险大幅增加有关.
- 严重体重不足与T2D患者的死亡风险比严重肥胖更大.
- 调查结果强调了解决T2D管理中的不足的重要性.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
4.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K
Diabetes: Symptoms, Diagnosis, and Complications
2.0K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.0K
Carbohydrate Metabolism
13.7K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
13.7K
Psychoneuroimmunology: Diabetes and Cancer
412
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
412
Diabetes Mellitus: Overview and Type I Subtype
4.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.8K
Drug Dosing: Obese Patients
202
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
202


