基于细胞的异构性纸再生的进展和前景
Yihan Chen1, Mingxin Hu1, Yan Lam Lee1
1Restorative Dental Sciences, Endodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong, SAR, China.
International endodontic journal
|December 6, 2025
概括
再生性内牙术程序显示了纸再生的希望,但面临着诸如低细胞存活率和免疫排斥等挑战. 未来的研究需要优化交付和免疫逃避策略,以获得临床成功.
科学领域:
- 牙周内科医院 牙周内科医院 牙周内科医院
- 干细胞生物学 干细胞生物学
- 免疫学 免疫学 免疫学
背景情况:
- 基于细胞的再生性内牙术程序 (REP) 显示出使用牙纸干细胞 (DPSC) 和来自人体脱皮脱落牙 (SHED) 的干细胞进行纸再生的潜力.
- 临床实施受到低细胞存活率,异构移植中的免疫排斥以及不一致的协议的阻碍.
研究的目的:
- 审查自主和异种DPSC/SHED移植的再生方法.
- 分析临床前和临床REP研究之间的差异.
- 探索非免疫反应的机制,并提出减少免疫排斥的策略.
主要方法:
- 在clinicaltrials.gov和PubMed上搜索了DPSC和SHED的临床试验和病例报告.
- 包括对特定细胞产品的研究,如NestaCell和Cellavita HD.
- 使用高级搜索过器查找病例报告和临床试验.
主要成果:
- 包括27个临床试验和11个病例报告,显示了REPs的有利结果.
- 临床前研究表明,体内细胞存活率有限,在压力条件下,DPSCs成为免疫原体.
- 已开发出延长DPSC生存的策略.
结论:
- 在标准化协议和细胞跟踪方面仍然存在重大局限性.
- 未来的研究应该专注于优化输送系统和免疫逃避细胞工程.
- 需要严格的临床试验设计,才能将REP推进到可预测的疗法.
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