全球肺功能倡议-2022的适用性,在伊拉克的健康成年人中使用螺旋计参考方程
Walid Al-Qerem1, Alaa Hussein Alsajri2, Anan Jarab3
1Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan.
The Libyan journal of medicine
|December 6, 2025
概括
全球肺功能倡议 (GLI) -2022方程低估了伊拉克成年人的肺功能,显示不适合和显著的年龄/身高变化. 区域验证对于准确的临床管理至关重要.
科学领域:
- 肺部医学 肺部医学
- 公共卫生 公共卫生
- 临床诊断 临床诊断 临床诊断
背景情况:
- 全球肺功能倡议 (GLI) 制定了种族中立的参考方程,以提高肺功能评估中的公平性和全球代表性.
- 对于GLI-2022方程在不同的人群中,特别是中东地区的适用性,需要进行彻底的调查.
- 准确的肺功能参考方程对于有效诊断和管理呼吸道疾病至关重要.
研究的目的:
- 在健康的伊拉克成年人中评估GLI-2022螺旋计参考方程的适用性和准确性.
- 评估肺功能测量中的潜在系统偏差和变异,使用GLI-2022方程在这个特定的人口群体中.
主要方法:
- 一项横截面研究包括3828名18岁及以上的健康,不吸烟的伊拉克成年人 (49.8%的女性).
- 获得了螺旋测量测量 (FVC,FEV1,FEV1/FVC),并使用GLI-2022方程计算了z-score.
- 使用线性回归和量子分析来评估与年龄和身高相关的平均z分数.
主要成果:
- 在伊拉克成年人中,GLI-2022方程系统地低估了肺功能 (FEV1,FVC),平均z-score超出了可接受的±0.5范围.
- 观察到显著的偏差,女性的平均z-score (FEV1: 1.18,FVC: 0.81) 和男性 (FEV1: 0.96,FVC: 0.61) 表示不适合.
- Z-分数显示了显著的年龄和身高依赖的变化,在男性中更明显,这表明高个子/老个体的高估.
结论:
- GLI-2022的种族中立方程不能充分代表伊拉克成年人口的肺功能.
- 系统的低估和与年龄/身高相关的变化凸显了在没有区域验证的情况下应用这些全球方程的局限性.
- 对于局部参考方程的需求至关重要,以确保伊拉克呼吸系统疾病的准确诊断和有效的临床管理.
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