感染和未感染SARS-CoV-2-家庭成员的持续症状:一个前性队列研究
Angelique M A M Winkel1,2, Bastienne A de Jonghe1, Coen R Lap1,3
1Spaarne Gasthuis Academy, Hoofddorp, The Netherlands.
Journal of medical virology
|December 6, 2025
概括
感染SARS-CoV-2的成年人经历了感染后六个月更持久的呼吸系统症状,疲劳和炼问题. 儿童很少报告长期症状,但成年人的持续问题与生活质量下降和焦虑增加有关.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 非住院的SARS-CoV-2感染可能导致持续的症状,影响个体的健康相关生活质量 (HRQoL).
- 了解SARS-CoV-2在不同年龄组的长期影响对于公共卫生管理至关重要.
研究的目的:
- 评估非住院 SARS-CoV-2 感染后持续症状的流行率,类型和后果.
- 为了比较荷兰家庭中受感染和未受感染个体之间的结果.
主要方法:
- 在两个流行病阶段进行的前性家庭研究.
- 在基线时对SARS-CoV-2进行RT-PCR唾液测试.
- 6个月和12个月评估持续症状,HRQoL,焦虑和抑郁症状的问卷.
主要成果:
- 在297名参与者中,201人检测出SARS-CoV-2阳性.
- 在6个月后,只有一个孩子报告了持续的症状.
- 与未感染的成年人相比,感染SARS-CoV-2的成年人报告了更多的肺部症状 (15.2%对3.4%),疲劳 (12.8%对3.4%),以及与炼相关的症状 (8.8%对1.7%).
- 成年人的持续症状与HRQoL降低,焦虑和抑郁症状增加有关.
结论:
- 感染后6个月,SARS-CoV-2-阳性成年人显示呼吸道,疲劳和炼症状的患病率较高.
- 儿童在感染SARS-CoV-2后很少出现持续的症状.
- 在SARS-CoV-2感染后持续的症状与HRQoL降低和心理痛苦增加有关.
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