克罗恩病中的分子和细胞生物标志物:从致病源到临床应用
Alexander Blagov1, Marina D Sazonova2, Anastasia I Ryzhkova3
1Laboratory of angiopathology, Institute of General Pathology and Pathophysiology, 8, Baltiiskaya Street, 125315 Moscow, Russia. al.blagov2014@gmail.com.
Cellular and molecular biology (Noisy-le-Grand, France)
|December 6, 2025
概括
诊断克罗恩病 (CD) 是很困难的. 本综述探讨了当前和新兴的生物标志物,如微RNA和代谢学,以改善早期检测和个性化治疗这种慢性炎症性肠病.
科学领域:
- 胃肠病学 胃肠病学
- 生物标志物发现发现
- 炎症性肠道疾病研究研究
背景情况:
- 克罗恩氏病 (CD) 是一种慢性炎症性肠病,由于其异质性和重叠的症状,诊断具有挑战性.
- 目前的诊断方法 (临床,内镜,组织学,成像) 通常是侵入性的和耗时的.
- 需要提高诊断准确度和减少侵入性,以便更好地管理患者.
研究的目的:
- 审查用于诊断克罗恩病的已确定的生物标志物.
- 探索具有提高诊断准确性潜力的新和新兴生物标志物.
- 讨论生物标志物的临床实用性和在日常实践中的应用.
主要方法:
- 对克罗恩病当前诊断生物标志物的文献综述.
- 通过基因组学,蛋白质组学和代谢组学识别新兴生物标志物的探索.
- 对生物标志物的性能特征和临床相关性的分析.
主要成果:
- 已知生物标志物包括C反应蛋白,便calprotectin和抗Saccharomyces cerevisiae抗体.
- 新兴的生物标志物包括microRNA面板,代谢学特征和新型炎症媒介.
- 基因组,蛋白质组和代谢组的进步为提高诊断精度提供了有希望的候选人.
结论:
- 可靠的生物标志物对于改善克罗恩病的早期和准确诊断至关重要.
- 新兴生物标志物显示出非侵入性诊断和个性化治疗策略的潜力.
- 进一步了解生物标志物性能对于临床实施和改善患者结果至关重要.
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