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Updated: Jan 9, 2026

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
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在自身免疫性疾病中通过综合生物信息学分析确定了共享的基因功能

Saniye Elvan Öztürk1

  • 1Aksaray University, Faculty of Science and Letters, Department of Molecular Biology and Genetics, Aksaray, Türkiye. saniyeelvanozturk@gmail.com.

Cellular and molecular biology (Noisy-le-Grand, France)
|December 6, 2025
PubMed
概括

环境因素显著影响自身免疫性疾病,而不是遗传学. 这项研究确定了关键的基因表达变化,包括LINC01833等非编码基因,用于自身免疫疾病中的潜在诊断和治疗标.

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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