乳腺癌治疗中的EGFR治疗对皮肤的不良影响
Tvisha Devireddy1, Clara Lim1, Jhillika Patel2
1Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Clinical and translational science
|December 6, 2025
概括
乳腺癌的表皮生长因子受体抑制剂 (EGFRI) 通常会引起皮肤毒性,影响患者的生活质量. 积极的管理和患者教育对于解决这些副作用至关重要.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 乳腺癌是美国女性的主要癌症.
- 表皮生长因子受体抑制剂 (EGFRI) 用于治疗乳腺癌,但通常会导致皮肤毒性.
- 这些皮肤毒性可能会对患者的生活质量和治疗坚持产生负面影响.
研究的目的:
- 审查乳腺癌治疗中与EGFRIs相关的皮肤不良影响的临床特征,机制和管理.
- 综合关于EGFRI诱导的皮肤毒性的当前文献.
主要方法:
- 对2014年至2024年间发表的研究进行了全面的PubMed搜索.
- 包括专注于接受EGFRI治疗的女性乳腺癌患者的研究,报告了皮肤副作用.
- 90篇文章符合本次审查的纳入标准.
主要成果:
- 皮肤毒性严重程度受患者因素 (年龄,遗传,生活方式) 和治疗因素 (剂量,组合疗法) 的影响.
- 常见的毒性包括乳头皮疹,,,脱发,以及严重的反应,如史蒂文斯-约翰逊综合征.
- EGFRI的类型 (单克隆抗体与氨酸激酶抑制剂) 影响了特定的皮肤反应.
结论:
- 由EGFRI引起的皮肤毒性显著影响乳腺癌患者的生活质量和治疗坚持.
- 积极的管理策略,包括预防性护理和症状治疗是必不可少的.
- 建议在治疗前为患者提供有关潜在皮肤不良影响的咨询,以提高意识和坚持.
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