在老年患者中对术后克罗恩病的管理和结果进行比较研究:来自ENEIDA注册表的数据
Míriam Mañosa1,2, Margalida Calafat1,2, Elena Ricart2,3
1Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
United European gastroenterology journal
|December 6, 2025
概括
克罗恩氏病 (CD) 的老年患者在肠切除后接受的术后预防疗法较少,但与年轻人相比,经历了类似的手术术后复发率 (POR).
科学领域:
- 胃肠病学 胃肠病学
- 外科胃肠道外科手术
- 老年医学 老年医学
背景情况:
- 关于老年患者手术后克罗恩病 (CD) 管理的数据有限.
- 在这个人口群体中评估手术术后复发 (POR) 是至关重要的.
研究的目的:
- 为了描述老年患者肠切除后CD的管理.
- 与年轻成年人相比,评估60岁以上患者的手术POR率.
主要方法:
- 一项病例控制研究使用了ENEIDA注册表.
- 分析了经历了第一次肠切除的成年CD患者,他们的肠道切除具有伊利欧结肠瘤.
- 患者被分为老年人 (>60岁) 或对照人 (18-60岁).
主要成果:
- 年龄较大的患者从CD诊断到手术的时间较长,周疾病或透性疾病较少.
- 较少的老年患者接受了POR的预防疗法 (32%对51%).
- 在3,5年和10年 (p=0.093) 的年龄组和年轻组中,手术POR的发病率相似.
结论:
- 老年患者在CD的肠切除后接受的术后预防性治疗较少.
- 尽管治疗减少了,但老年患者的手术POR率与年轻人相似.
- 在多变量分析中,提奥普林预防与降低POR风险有关.
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