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在儿科心脏重症监护病房内进行外科连续输液:一项25年后期研究
Oluwatomini A Fashina1, Grace M Arteaga2, Sheri S Crow2
1Department of Pediatrics, Mayo Clinic, Rochester, MN, USA. tominifashina@gmail.com.
Pediatric cardiology
|December 6, 2025
概括
在儿科心脏重症监护中,研究了用于镇静的连续普罗波福尔输液. 在手术后的先天性心脏病患者中,没有观察到与醇相关的输液综合征 (PRIS) 的病例.
科学领域:
- 儿科重症监护医学 儿科重症监护医学
- 心脏病学 心脏病学
- 麻醉学 麻醉学
背景情况:
- 儿科心脏病重症监护需要定制麻醉和镇静,因为独特的患者脆弱性.
- 连续输注普罗波福尔经常用于儿童心脏重症监护室 (PCICU) 的镇静.
- 甲醇相关输液综合征 (PRIS) 是一种罕见但严重的并发症,与甲醇使用有关.
研究的目的:
- 为了评估手术后先天性心脏病患者中PRIS的发病率,这些患者接受连续的propofol输液.
- 评估在这个特定的高风险儿科患者群体中使用普罗波的安全性.
- 在PCICU患者中识别潜在的风险因素或与PRIS的关联.
主要方法:
- 对641名手术后先天性心脏病患者 (<18岁) 的回顾性审查,这些患者被录入PCICU.
- 纳入标准:连续输注醇≥12小时和/或≥2.4毫克/公斤/小时.
- 分析包括PRIS发病率,ICU停留时间,存活率和按生理复杂性和手术风险得分分层分的分层.
主要成果:
- 在研究队列中没有报告PRIS病例.
- 中位普罗波福尔输液速率为1.2mg/kg/小时,平均持续时间为22.7小时.
- 医院出院的存活率为97%,ICU住院时间中位数为7.1天.
结论:
- 在这项单中心研究中,在术后先天性心脏病患者中持续输注普罗波与PRIS无关.
- 研究结果支持在儿科心脏病重症监护中谨慎使用普罗波进行镇静.
- 建议进行进一步的前性研究,以确认各种先天性心脏病人群的安全性,包括单心室生理学.
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