饮食中使用的 melegueta 种子粉可以调节生长,肝功能和生物标志物,以抵消 brojlers 中的 aflatoxin B1 毒性
Olugbenga David Oloruntola1, Ilesanmi Ogunji2, Andrew Bamidele Falowo2
1Department of Animal Science, Adekunle Ajasin University, Akungba Akoko, Nigeria. olugbenga.oloruntola@aaua.edu.ng.
Mycotoxin research
|December 6, 2025
概括
阿弗拉莫米勒盖塔 (Aframomum melegueta) 种子粉 (AMSP) 有效地保护肉免受阿弗拉托克辛B1 (AFB1) 毒性,恢复生长性能并减轻肝脏损伤. 这种天然补充剂有望改善家禽健康和料安全.
科学领域:
- 禽畜科学 禽畜科学 禽畜科学
- 毒理学 毒理学 毒理学
- 自然产品化学 自然产品化学
背景情况:
- 甲毒素B1 (AFB1) 是一种真菌毒素,在肉中引起显著的毒性,影响生长和健康.
- 植物性补充剂,如Aframomum melegueta种子粉 (AMSP) 具有抗氧化和抗炎性质,可以抵消AFB1的影响.
研究的目的:
- 评估Aframomum melegueta种子粉 (AMSP) 在保护肉免受阿弗拉托克辛B1 (AFB1) 诱导的毒性方面的有效性.
- 评估AMSP补充对AFB1暴露肉生长表现,生化参数和肝脏组织病理学的影响.
主要方法:
- 植物化学查和AMSP的抗氧化活性测定.
- 一个养试验,使用320只Cobb 500肉小分为四组:对照组,AFB1暴露组和AFB1暴露组,两种水平的AMSP (0.5g/kg和1.0g/kg).
- 在六周内评估生长性能,血液学,血清生物化学,炎症标志物和肝脏组织病理学.
主要成果:
- 暴露于AFB1显著损害了 brojler 的生长,减少了细胞密集量和血红蛋白,增加了肝酶 (ALT,AST),肌素和炎症标志物 (TNF-α,IL-6),同时抑制了IL-10.
- 补充AMSP,特别是1.0g/kg,有效地恢复了生长性能,使生物化学和血液学参数正常化,并减轻了肝损伤.
- 组织病理学分析证实,AMSP减轻了AFB1诱导的肝炎和结构损伤.
结论:
- 在1.0g/kg的Aframomum melegueta种子粉 (AMSP) 是一种有效的天然料添加剂,可减轻 brojler的 aflatoxin B1 (AFB1) 毒性.
- AMSP显示了提高家禽健康,提高料安全的潜力,并要求进一步研究商业应用.
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