氨酸和富含氨酸的食物对认知功能的影响:随机对照试验的元分析
Agnieszka Micek1, Justyna Godos2, Francesca Giampieri3,4,5
1Statistical Laboratory, Faculty of Health Sciences, Jagiellonian University Medical College, 31-501, Cracow, Poland.
GeroScience
|December 6, 2025
概括
安东素补充剂显著提高了全球认知和特定的认知领域,如记忆和处理速度. 这些发现表明,安东素可能对认知健康有益,因此需要进一步研究.
科学领域:
- 营养神经科学 营养神经科学
- 认知健康 认知健康
- 植物生物活性物质
背景情况:
- 认知障碍正在增加,需要有效的预防和治疗策略.
- 饮食因素,特别是植物衍生化合物,如安东素,在缓解认知衰退方面显示出有前途.
- 一种类型的黄类药物安托西亚宁因其潜在的认知益处而引起了人们的注意.
研究的目的:
- 使用元分析系统地评估富含安东的干预措施对认知表现的影响.
- 综合来自随机对照试验 (RCT) 关于安素补充和认知结果的证据.
主要方法:
- 为了确定相关的RCT,进行了全面的系统搜索.
- 在元分析中包括了59项符合条件的研究,调查了安托素补充剂和认知结果.
- 使用统计分析,包括标准化平均差异 (SMD),来评估整体和特定领域的影响.
主要成果:
- 安索亚宁干预表明全球认知显著改善 (SMD = 0.46).
- 在多个认知领域观察到显著的益处:视觉空间处理/推理和注意力 (SMD = 0.37),处理和精神运动速度 (SMD = 0.19),口语速度和流利性 (SMD = 0.21),情节性记忆 (SMD = 0.30) 和工作记忆 (SMD = 0.24).
- 对于全球认知,观察到的异质性较低,而对于一些特定领域的分析,观察到中等到高的异质性.
结论:
- 安东素补充似乎对各种认知功能产生积极影响,包括全球认知和特定领域.
- 这些发现表明,安东素在支持认知健康方面可能发挥作用.
- 建议进一步进行高质量的RCT,以确认这些结果并加强证据基础.
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