抗Tr/DNER抗体相关的神经神经综合征与小瘤复杂:一个病例报告和文献综述
Sufen Huang1,2, Yuzhang Bei2, Qingxiang Zhang3
1Department of Neurology, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China.
Cerebellum (London, England)
|December 6, 2025
概括
这一病例突出显示了一种罕见的瘤神经综合征 (PNS) 呈现,与抗三角形/状表皮生长因子相关受体 (anti-Tr/DNER) 抗体有关. 它表明PNS可以发生在良性瘤中,如Wartin瘤,而不仅仅是恶性瘤.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 麻性神经综合征 (PNS) 通常涉及与表皮生长因子相关的受体 (anti-Tr/DNER) 抗体,小脑缩症和霍奇金淋巴瘤.
- 在抗Tr/DNER抗体相关的PNS中,脑外症状和没有恶性病变的表现不常见.
研究的目的:
- 报告一种罕见的可能带有抗Tr/DNER抗体的PNS病例.
- 描述临床表现,诊断发现和治疗结果.
- 扩大已知的抗Tr/DNER疾病的表型,特别是在没有恶性瘤的情况下.
主要方法:
- 一个60岁的病人的病例报告,有神经症状和部质量.
- 对抗Tr/DNER抗体进行血清和脑脊液 (CSF) 检测.
- 部质量的组织病理学检查.
- 神经学评估和对治疗的反应.
主要成果:
- 患者出现了扫描语音,近端肢体的软弱和步态无力.
- 血清和脊髓中抗Tr/DNER抗体呈阳性.
- 部质量病理学证实了一个良性小瘤.
- 在用静脉注射免疫球蛋白和德克萨米他治疗后,观察到神经系统的改善.
结论:
- 这种病例代表了与抗Tr/DNER抗体和良性Warthin瘤相关的可能的瘤神经综合征.
- 它扩大了对抗Tr/DNER抗体疾病的临床表现的范围.
- 强调抗体检测对于快速进展的小脑动症的重要性,即使没有明显的恶性病变.
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