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Updated: May 5, 2026

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罗伊福林通过调节SESN2来调节Keap1/Nrf2和AMPK/Nox通道来抑制小鼠的神经氧化损伤,从而防止简单疹病毒脑炎

Wenhui Yang¹, Xi Chen¹, Danwen Wang¹

¹School of Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.

Phytomedicine : international journal of phytotherapy and phytopharmacology

|December 6, 2025

概括

罗伊福林 (ROF) 通过减少病毒复制和氧化应激,有效地治疗小鼠的简单疹脑炎 (HSE). 这种天然化合物提供神经保护并减少神经炎症,改善HSE模型的结果.

科学领域:

神经科学是一个神经科学.
病毒学病毒学
药理学药理学是指药理学的学科.

背景情况:

简单疹脑炎 (HSE),主要是由简单疹病毒1型 (HSV-1) 引起的,是一种严重的全球性疾病,死亡率高,神经系统后果严重.
目前的治疗方法,如阿西克洛维尔 (ACV) 有局限性,需要新的治疗策略.
罗伊福林 (ROF) 是一种植物性化合物,具有与HSE病理相关的已知的抗氧化,抗炎和神经保护性质.

研究的目的:

评估罗伊福林 (ROF) 在单纯疹脑炎 (HSE) 的小鼠模型中的治疗疗效.
阐明ROF对HSE施加保护作用的抗病毒和机械途径.

主要方法:

利用致命的HSE小鼠模型和HSV-1感染的神经细胞培养物来评估ROF的疗效.
采用分子生物学和体化学技术来研究ROF作用的潜在机制.

主要成果:

在具有致命HSE的小鼠中,ROF显著提高了生存率.
在神经细胞中,ROF在神经细胞中显示出对HSV-1的抗病毒活性 (EC50:4.155.30μM).
通过调节Sestrin2 (SESN2) /Keap1/Nrf2和AMPK/Nox通路,ROF减轻了氧化应激和炎症.

结论:

通过抑制病毒复制和氧化应激,ROF治疗有效地对抗致命的HSE.
ROF增强SESN2表达,并调节关键下游通路 (Keap1/Nrf2,AMPK/Nox),减少神经损伤和神经炎症.

关键词:

医疗卫生与社会服务局 (HSE) 负责.在HSV-1病毒中,神经氧化损伤神经氧化损伤氧化应激是一种氧化应激.在ROF中,可以使用ROF.这就是SESN2的意义.

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