在超声波引导的星状质块后,对心率变异的选择性同情作用
Ole C Keim1, Raoul C Raum2, Robert E Feldmann2
1Department of Anesthesiology, Heidelberg University Hospital, Germany.
Autonomic neuroscience : basic & clinical
|December 6, 2025
概括
超声导向的星状质块 (SGB) 选择性地抑制心脏交感活动,而不会影响阴道声调,如心率变化 (HRV) 变化所证明的那样. 这项研究证实了SGB的存在.
科学领域:
- 心血管生理学心血管生理学
- 自主神经系统研究 自主神经系统研究
- 干预性疼痛管理 干预性疼痛管理
背景情况:
- 星状质 (SG) 是交感神经系统的关键组成部分,影响心脏功能.
- 星状质块 (SGB) 对心率变化 (HRV) 的确切影响尚未完全理解.
- 迷走神经与SG的解剖学近距离引发了关于潜在的非选择性阻塞的问题.
研究的目的:
- 用超声波引导的SGB来研究对心脏的交感纤维选择性阻塞.
- 评估超声波引导的SGB对HRV的影响.
- 为了确定SGB是否会影响阴道音调.
主要方法:
- 一个安慰剂控制的,双盲,参与者内部试验,涉及12名健康的男性志愿者.
- 右侧超声引导的SGB使用1%的罗皮瓦卡因 (血清) 或0.9%的盐液 (安慰剂) 进行.
- 在干预之前和之后测量了心率变化 (HRV).
主要成果:
- 在Verum和安慰剂组之间没有观察到时间域HRV指数的显著变化.
- 在手术前后检测到低频/高频 (LF/HF) 比率的显著差异.
- 在LF/HF比率的变化表明选择性同情调制.
结论:
- 超声波引导的SGB有效调节心脏交感活动.
- 该程序表明选择性交感抑制,而不会显著改变阴道音调.
- 人力资源价值分析提供了SGB自主效应的可量化的衡量标准.
相关概念视频
Drugs Acting on Autonomic Ganglia: Blockers
1.6K
Ganglionic blockers inhibit autonomic activity by blocking nicotinic receptors in the autonomic ganglia, suppressing impulse transmission. These blockers lack selectivity between sympathetic and parasympathetic ganglia and are ineffective as neuromuscular junction antagonists. They can be categorized into two groups:
1.6K
Regulation of Heart Rates
3.7K
The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
3.7K
Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacological Actions
857
Nondepolarizing neuromuscular blockers prevent the membrane depolarization of muscle cells and inhibit muscle contraction. These are usually administered with anesthetics to achieve complete muscle relaxation. Upon administration, these drugs first block the small, rapidly contracting muscles of the face and hands, followed by the larger muscles of the trunk and the intercostal muscles. The diaphragm is the last muscle to be affected.
Although all competitive neuromuscular blockers are designed...
Although all competitive neuromuscular blockers are designed...
857
Heart Failure Drugs: β-Blockers
737
β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
737
Sympathetic Activation
6.5K
The sympathetic division can influence tissues and organs by releasing norepinephrine at peripheral synapses and distributing epinephrine and norepinephrine through the bloodstream. In times of crisis or stress, sympathetic activation occurs, which is regulated by sympathetic centers in the hypothalamus. As a result, sympathetic activation prepares the body for physical exertion, rapid ATP production, and heightened alertness, allowing individuals to respond effectively to challenging or...
6.5K
Sympathetic Signaling
2.1K
Sympathetic signaling, a vital part of the autonomic nervous system, plays a crucial role in mobilizing the body's resources in response to stress or emergencies. It involves the transmission of nerve impulses from sympathetic preganglionic fibers to postganglionic fibers. This results in the release of specific neurotransmitters and activation of adrenergic receptors.
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
2.1K


