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在地铁工人中,口腔细胞中的微核频率随着尿液度和氧化应激生物标志物的增加而增加

Nancy B Hopf¹, Mélanie Graille¹, Kakima Kastuganova²

¹Unisante, University Center for Primary Care and Public Health & University of Lausanne, Switzerland.

Environment international

|December 6, 2025

概括

在口腔细胞中的微核 (MN) 试验检测出基因毒性. 地铁工人接触到低水平的颗粒物显示增加了与尿路和氧化应激生物标志物相关的MN频率.

科学领域:

环境健康环境健康
生物标志物生物标志物
基因毒理学基因毒理学

背景情况:

微核 (MN) 试验是一种非侵入性基因毒性生物标志物.
评估使用MN测定对颗粒物 (PM) 暴露的剂量反应关系是有限的.
地铁颗粒物暴露给生物标志物评估带来了独特的挑战.

研究的目的:

评估在口腔细胞中MN频率与地铁中PM暴露之间的关联.
研究MN频率与氧化应激和新陈代谢的生物标志物之间的联系.
确定MN频率是否反映了低暴露环境中的系统生物效应.

主要方法:

招募了303名巴黎地铁工人,收集口腔细胞样本.
量化尿液和呼气中的凝聚金属度 (ICP-MS).
分析了效果生物标志物 (LC-MS) 和评估了与MN频率 (Poisson回归) 的关联.

主要成果:

尿液度显著与增加的MN频率相关 (RR=2.013,p=0.004),尽管暴露率低.
氧化应激生物标志物 (氨酸,8-基-2'-脱氧氨酸) 与更高的MN频率相关 (RR=1.214,p=0.045).
女性的MN频率明显低于男性;与PM10或就业时间无关.

结论:

尿和氧化应激生物标志物与口腔细胞中MN频率有关.
即使在低暴露水平下,MN频率也可能表明系统性生物效应.
该研究强调了MN测定在环境暴露评估中的有用性.

关键词:

8OHdG是什么意思 8OHdG是什么意思基因毒性基因毒性在MDA中,MDA是MDA.这是一个微核.职业暴露职业暴露职业暴露地铁地铁地铁地铁地铁的是什么? 的是什么?

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