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相关概念视频

Long-term Potentiation01:35

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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A schema is a mental framework that helps individuals organize and interpret information. Schemata, formed from previous experiences, influence how we process new information: how we encode it, the inferences we make, and how we retrieve it. For instance, a schema for what a typical classroom looks like might include desks, a teacher's desk, a whiteboard, and students in such an environment. This expectation helps us quickly understand and navigate new classrooms without needing to analyze...
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Memory is the retention of information or experiences over time, facilitated through three main processes: encoding, storage, and retrieval. Encoding is the process of inputting information into the memory system. For instance, when listening to a lecture, watching a play, reading a book, or having a conversation, the brain is actively encoding information. This initial stage involves transforming sensory input into a form that can be processed and stored by the brain. Various factors, such as...
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Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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相关实验视频

Updated: Jan 9, 2026

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
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内在的神经时间尺度塑造了记忆编码和检索.

Xinyu Shen1, Xiaoyu Cui1, Yasir Çatal2

  • 1Center on Aging Psychology, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.

NeuroImage
|December 6, 2025
PubMed
概括

大脑是大脑的大脑.

关键词:
自动关联窗口自动关联窗口脑电图, 认知动力学内在的神经时间尺度.记忆中的编码和检索.时间整合和隔离.

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Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
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科学领域:

  • 神经科学是一个神经科学.
  • 认知心理学 认知心理学

背景情况:

  • 编码和检索是不同的记忆过程.
  • 最近的模型表明编码和检索之间的连续性.
  • 跨时间尺度的这些过程背后的神经机制尚不清楚.

研究的目的:

  • 在记忆编码和检索过程中调查大脑的内在神经时间尺度 (INT).
  • 检查INT如何连接和区分这些记忆阶段.
  • 确定INT对内存性能的预测能力.

主要方法:

  • 使用脑电图 (EEG) 来测量自相关窗口 (ACW) 作为INT的代理.
  • 在记忆编码 (空间适合判断) 和检索任务期间记录的ACW.
  • 评估行为指标,包括精度,错误报警和准确性.

主要成果:

  • 在编码和检索性能之间发现了直接的行为联系.
  • 观察到状态依赖的神经差异化:编码 (整合) 期间较长的ACW和检索 (分离) 期间较短的ACW.
  • 在休息和记忆状态中表现出稳定的,类似特征的ACW,预测更高的记忆精度和更少的错误报警.

结论:

  • 通过ACW测量的大脑的INT,既连接又区分记忆编码和检索.
  • 类似特征的ACW稳定性对于预测内存性能至关重要.
  • 这些发现支持记忆的动态时间模型,突出了INT的作用.