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在降低强度调节后优化患者选择以减少非复发性死亡率:CIBMTR分析

Yu Akahoshi¹, Nelli Bejanyan², Hideki Nakasone³

¹Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

Transplantation and cellular therapy

|December 6, 2025

概括

老年患者的强度调节疗法的风险评估 (RICE) 评分有效预测在接受异构造血细胞移植 (HCT) 的西方患者中非复发性死亡率 (NRM). 它有助于个性化调节强度选择,以改善移植结果.

科学领域:

血造细胞移植 (HCT) 的方法
在瘤学瘤学.
免疫学免疫学免疫学

背景情况:

降低强度调节 (RIC) 提供较低的非复发死亡率 (NRM),但较高的复发风险比骨髓衰变调节 (MAC) 在全基性HCT.
老年患者强度调节疗法的风险评估 (RICE) 评分是为了确定受益于RIC的患者而开发的.
瑞斯评分使用了老年,高并发病率和带血液捐献者身份.

研究的目的:

为了评估RICE评分在西方人口中的适用性.
使用CIBMTR数据集验证RICE得分.

主要方法:

对2595名年龄在40-65岁之间的患者进行分析,这些患者接受了针对AML和MDS的首次HCT (2009-2015).
主要终点:NRM,按条件强度和RICE得分分层.

主要成果:

在低RICE分数患者中,MAC显示类似NRM但复发率较低,改善无病生存率 (DFS).
在高RICE得分的患者中,RIC显著降低了NRM与MAC,尽管DFS由于RIC复发率较高而相似.

结论:

在西方群体中,RICE评分是外部验证的.
RICE评分可以根据个体风险因素指导调节强度的选择.
这种工具可以通过改进NRM风险评估来改善HCT结果.

关键词:

调节强度的调节强度.没有复发的死亡率.个性化医疗是个性化的医疗.

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