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功能化聚多巴胺涂层纤维素纳米晶作为pH响应的纳米载体,用于准黄素的向输送

Ziqi Li¹, Yuying Wang², Wengang Chen³

¹Department of Pharmacy, Jiangxi Maternal and Child Health Hospital, Nanchang, 330006, China.

International journal of biological macromolecules

|December 6, 2025

概括

这项研究提出了针对肝细胞癌 (HCC) 治疗的pH响应纳米载体. 该系统有效地将黄素 (Cur) 传递给癌细胞,在酸性瘤环境中释放,以提高疗效.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
癌症治疗方法癌症治疗方法

背景情况:

针对性和刺激响应的药物递送系统 (DDS) 对于提高癌症治疗效率和减少副作用至关重要.
肝细胞癌 (HCC) 需要创新的治疗策略,特别是用于提供水溶性较差的药物,如黄素 (Cur).

研究的目的:

开发一种pH响应的纳米载体,用于积极向HCC细胞.
为了使黄素 (Cur) 在响应酸性瘤微环境的过程中得到控制的释放.
为了评估纳米载体在HCC治疗中体外的疗效.

主要方法:

用聚多巴胺 (PDA) 和3-碳烯酸 (CA) 对纤维素纳米晶体 (CNC) 的表面修饰,以创建CNCs@PDA-CA.
在纳米载体上通过酸盐链接加载黄素 (Cur),形成CNCs@PDA-CA-Cur.
在HCC模型中评估药物负载能力,pH响应释放,活性向,细胞内积累和细胞毒性.

主要成果:

最终的纳米复合材料CNCs@PDA-CA-Cur实现了10.58±1.32%的药物载荷能力.
该纳米载体表现出显著的pH响应的Cur释放,在酸性 (pH5.4) 与中性 (pH7.2) 条件下释放的3.18倍.
观察到对HCC细胞的有效主动向,导致细胞内Cur积累增加,并在体外增强细胞毒性.

结论:

开发的向和pH响应的纳米载体显示了改善HCC难溶药物的治疗输送的希望.
这种DDS策略提供了一种潜在的方法来提高治疗效率,并尽量减少肝细胞癌治疗中的不良影响.

关键词:

3 - 碳基烯基酸是什么纤维素纳米晶体纤维素纳米晶体多巴胺化药物向药物提供提供响应pH的反应性

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