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市政卫生工作人员的职业接触甲酸和全身临床变化:人类生物监测和网络分析方法

Mahbubeh Tangestani¹, Niloufar Borhani Yazdi², Hossein Arfaeinia³

¹Addiction and Lifestyle Research Center, Bushehr University of Medical Sciences, Bushehr, Iran.

Environmental pollution (Barking, Essex : 1987)

|December 6, 2025

概括

职业暴露于酸 (PAE) 显著提高了废物工作者中的代谢物水平,影响了血液细胞计数,肝酶和甲状腺激素. 这些发现突出了健康风险和需要在这个人群中采取保护措施的需要.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
职业医学职业医学是专业的.

背景情况:

酸乙 (PAE) 是常见的增塑剂,与不良健康结果有关.
职业接触PAE是一个越来越令人担忧的问题,特别是在废物管理部门.

研究的目的:

评估市政废物收集工作者对PAE代谢物的职业暴露.
为了比较PAE代谢物水平和废物工作者和对照组之间的健康生物标志物.

主要方法:

从90名废弃物工作者和90名控制人员的血清中量化PAE代谢物.
评估了血液学,生物化学,炎症,氧化应激,肝脏,甲状腺和功能生物标志物.
利用网络分析来确定PAE暴露和生理变化之间的关联.

主要成果:

垃圾处理人员的PAE代谢物水平显著更高 (25.66 ± 12.81 μg/L与15.03 ± 5.14 μg/L相比).
暴露的工人显示出改变的血液指数 (减少白血球,HB;升高的红血球,乙蛋白),升高的肝酶,甲状腺激素 (T3,T4) 和炎症标志物 (TNF-α,IL-6).
网络分析将PAE暴露与中性粒细胞,氧化应激标记OHdG8,甲状腺参数和凝血时间 (PT,PTT) 的显著变化联系起来.

结论:

职业暴露是市政卫生工作者中PAE代谢物的主要来源.
暴露于PAE与显著的多系统生理变化有关,包括血液学,甲状腺和炎症反应.
调查结果强调了对高暴露环境中的工人进行预防策略和持续健康监测的必要性.

关键词:

生物标志物生物标志物炎症性细胞因子是可以引起炎症的.城市废物工作者网络分析网络分析氧化应激是一种氧化应激.甲酸的含量甲酸的含量

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