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Updated: Jan 7, 2026
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A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
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在初始诊断时患有本地区域性疾病的患者和在随访期间在进展后患有本地区域性疾病的患者之间,黑色素瘤的预后差异
A Luna1, A Alkhawaja2, D Rizo2
1Departamento de Dermatología, Hospital Clinic of Barcelona, University of Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain.
Actas dermo-sifiliograficas
|December 6, 2025
概括
在初始诊断后发生的III期黑色素瘤患者的生存结果略有差. 这项研究将初始III期黑色素瘤 (iSIII) 与进展到III期 (pSIII) 的黑色素瘤进行了比较,发现pSIII患者的黑色素瘤特异性存活率和整体存活率较差.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 临床研究 临床研究
背景情况:
- 第三阶段皮肤黑色素瘤是异质的,目前的阶段不区分诊断时间.
- 基于初始诊断和后进展的子组可能表现出不同的行为.
- 缺乏关于这些第三阶段黑色素瘤亚组之间的生存差异的数据.
研究的目的:
- 分析最初诊断的第三阶段黑色素瘤患者 (IIIB-D) 与初始诊断后进展到IIIB-D阶段的患者的生存差异.
- 为了比较发生和渐进的III阶段黑色素瘤队列之间的临床和组织病理学特征.
- 确定第三阶段诊断的时间是否会影响黑色素瘤特异性生存率 (MSS) 和整体生存率 (OS).
主要方法:
- 一项队列研究包括了939名在1998年至2022年期间被诊断患有皮肤黑色素瘤的患者.
- 患者被分为事件阶段III (iSIII) 和进展阶段III (pSIII) 队列.
- 考克斯回归分析用于评估黑色素瘤特异性存活率 (MSS) 和整体存活率 (OS).
主要成果:
- 该研究包括iSIII队列中的608名患者和pSIII队列中的331名患者.
- 在iSIII组中,原发性黑色素瘤更厚,具有更高的线粒体指数,并更频繁地发 (p<.001).
- 与iSIII队列相比,pSIII队列的MSS (HR 1.32) 和OS (HR 1.40) 略差一些.
结论:
- 尽管最初的原发性瘤攻击性较低,但进步的III阶段黑色素瘤 (pSIII) 队列的生存结果更差.
- 进入第三阶段黑色素瘤 (pSIII) 的患者的黑色素瘤特异性存活率 (MSS) 和整体存活率 (OS) 略低于最初诊断的患者 (iSIII).
- 这些发现突出了基于第三阶段黑色素瘤诊断时间的明显预后影响.
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