三甘油糖-一个身体形状指数 (TyG-ABSI) 作为潜在的认知障碍指标:来自两个全国代表性队列研究的结果
Zhiyue Liang1, Licong Su2, Yu Shi3
1Department of Biostatistics, School of Public Health (Guangdong Provincial Key Laboratory of Tropical Disease Research), Southern Medical University, Guangzhou, Guangdong, China; Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Journal of affective disorders
|December 6, 2025
概括
结合的甘油三-葡萄糖指数和身体形状指数 (TyG-ABSI) 与美国和中国成年人的认知障碍风险密切相关. 这一指数比其他指数更有效地识别了面临认知衰退风险的个体.
科学领域:
- 代谢健康和认知功能研究.
- 慢性疾病的流行病学.
- 开发用于健康风险评估的生物标志物.
背景情况:
- 三甘油-葡萄糖指数和身体形状指数 (TyG-ABSI) 与认知障碍之间的关系尚未得到充分理解.
- 现有的研究还没有广泛地探索这种跨不同人群的综合指数.
研究的目的:
- 调查TyG-ABSI指数与美国和中国成年人的认知障碍之间的关联.
- 将TyG-ABSI的预测性能与其他认知障碍指数进行比较.
主要方法:
- 美国 (NHANES) 和中国 (CHARLS) 成年人口的横截面分析.
- 使用生存分析 (Kaplan-Meier,Cox模型) 对CHARLS队列的纵向分析.
- 使用后勤回归,ROC曲线和DeLong测试来评估关联和歧视能力.
主要成果:
- 在横截面和纵向分析中,TyG-ABSI与认知障碍有显著的关联.
- 与其他指数相比,TyG-ABSI指数显示了认知障碍的优异预测性能.
- 高TyG-ABSI水平与累积发病率最高和随时间推移认知障碍风险增加有关.
结论:
- 泰格-ABSI指数显示,与认知障碍风险有显著的关联.
- TyG-ABSI是一个临床上有用且广泛适用的工具,用于识别有认知障碍风险的个体.
- 该指数在不同人群中提供了增强的预测能力.
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