基于水凝的药物输送系统用于局部消灭细菌生物膜:进展,挑战和未来方向
Amalie Kjær Andresen1, Mathilde Sophie Felding1, Margarida M A Sacramento2
1Department of Health Technology, Technical University of Denmark, Oersteds Plads 345C, 2800 Kgs. Lyngby, Denmark.
概括
水凝为细菌生物膜的根除提供了有希望的局部传递,克服了抗生素耐药性. 进一步的研究需要动态生物膜模型用于临床翻译.
科学领域:
- 生物材料科学 生物材料科学
- 传染性疾病 传染性疾病
- 药物运输 药物运输 药物运输
背景情况:
- 由于抗生素耐药性和免疫逃避,细菌生物膜存在重大临床挑战.
- 传统的全身抗生素治疗通常对结构化的微生物群体无效.
- 局部化,有针对性的药物输送系统对于有效的生物膜根除至关重要.
研究的目的:
- 审查基于水凝的细菌生物膜根除策略的进展.
- 为了突出响应刺激的水凝和协同作用的药物,以提高抗生素膜的疗效.
- 确定水凝疗法临床转化方面的挑战和未来方向.
主要方法:
- 探索水凝的特性:粘粘性,热敏性,杀菌性和刺激反应性.
- 专注于对生物膜微环境 (pH,酶,ROS) 产生反应的水凝,以便按需释放药物.
- 包括协同作用的药物,如抗微生物 (AMP),酶和细菌菌体.
主要成果:
- 水凝提供了一个多功能平台,用于局部抗微生物剂的控制释放.
- 刺激反应性水凝可以在感染部位释放有针对性的药物.
- 协同作用的药物显著提高水凝系统的抗菌膜疗效.
结论:
- 基于水凝的药物输送系统显示出局部生物膜消除的重大前景.
- 目前的临床前模型往往无法在体内条件下复制,因此需要改进动态生物膜模型.
- 治疗实施需要在临床相关条件下进一步验证.
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