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Updated: Jan 9, 2026

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
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通过调节雌激素/GPER-信号通路,RGS12以性别依赖的方式控制疼痛/机械敏感性

Chunbao Rao1, Mayank Gautam2, Shu-Ting Yang1

  • 1Department of Basic & Translational Sciences, School of Dental Medicine, University of Pennsylvania, USA.

The journal of pain
|December 6, 2025
PubMed
概括

调节G蛋白信号12 (RGS12) 的调节器在雌性和雄性小鼠中不同调节疼痛敏感性. 在女性中,RGS12的丧失降低了疼痛敏感性,与雌激素受体通路有关.

关键词:
背部根结节的结节.雌激素是一种雌激素.性别 性别 性别 性别疼痛的敏感性 疼痛的敏感性在RGS12中,使用的是RGS12.

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