来自乳母乳的母细胞对新生儿羔羊免疫反应对常规管理实践的影响
Mohamed A Donia1, James F Lowe2, Federico A Zuckermann3
1Department of Pathobiology, College of Veterinary Medicine, University of Illinois Urbana-Champaign, IL 61802, USA; Department of Animal Medicine (Internal Medicine), Kafrelsheikh University, Kafrelsheikh 33516, Egypt.
Veterinary journal (London, England : 1997)
|December 6, 2025
概括
与无细胞母乳 (CFC) 相比,母乳中的母乳细胞 (CRC) 改善了羔羊的健康状况,减少了寄生虫的流失,并增强了伤口愈合. 这些发现凸显了为畜牧业保存结肠细胞的好处.
科学领域:
- 兽医科学 兽医科学 兽医科学
- 动物科学动物科学
- 免疫学 免疫学 免疫学
背景情况:
- 大奶粉对新生的反动物至关重要,提供营养和免疫支持.
- 假设母乳中的母细胞可以增强新生儿免疫发育和长期健康.
- 这项研究调查了这些母细胞对羔羊健康结果的特定影响.
研究的目的:
- 为了评估细胞丰富的胆乳 (CRC) 与无细胞胆乳 (CFC) 对羊羔生长的影响.
- 评估CRC和CFC对畜牧业相关的粘膜健康挑战的影响,包括寄生虫感染和伤口愈合.
- 确定结肠细胞生存能力对畜牧业管理的实际影响.
主要方法:
- 建立了一种有效的方法来从绵羊胆乳中去除母细胞.
- 双胞胎羔羊 (n=78) 在出生后12小时内被食CRC或CFC,经过两次养季节.
- 监测羊羔的体重增加,寄生虫的脱落 (coccidia,strongyloids),以及围膜炎症/割后的愈合.
主要成果:
- 食细胞丰富乳酪粉 (CRC) 的羊羔表现出明显较低的菌卵囊数量 (p=0.04).
- 与CFC羊羔相比,CRC羊羔表现出改善的割后愈合得分和减少的胀 (p<0.05多个时间点).
- 虽然体重增加没有统计学意义,但CRC羔羊随着时间的推移显示出一致的增加.
结论:
- 结肠杆细胞给羔羊带来了显著的健康益处,包括减少寄生虫负担和增强伤口愈合.
- 这些发现强调了乳酪管理策略的重要性,这些策略可以保护母细胞的活力.
- 需要进一步的研究来阐明驱动这些观察到的健康改善的特定细胞机制.
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