微生物群和癌症免疫疗法:机制,临床影响和精确治疗方法
Dongliang Wei1, Yilan Sun1, Jing Han1
1Department of Oral and maxillofacial Head and neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, PR China; College of Stomatology, Shanghai Jiao Tong University, Shanghai 200001, PR China; National Center for Stomatology, Shanghai 200001, PR China; National Clinical Research Center for Oral Diseases, Shanghai 200001, PR China; Shanghai Key Laboratory of Stomatology, Shanghai 200001, PR China; Shanghai Research Institute of Stomatology, Shanghai 200001, PR China.
肠道微生物群影响癌症免疫疗法的有效性和副作用. 精确的微生物干预措施有望改善癌症治疗结果和患者护理.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 微生物组研究的研究.
背景情况:
- 肠道微生物组显著影响癌症免疫疗法的疗效和毒性.
- 微生物群落和代谢物调节宿主免疫力和瘤微环境.
- 微生物组失调与免疫相关的不良事件 (irAEs) 有关.
研究的目的:
- 审查微生物组-免疫-瘤学轴.
- 探索机制的基础和翻译的挑战.
- 讨论癌症免疫治疗的基于微生物组的创新治疗策略.
主要方法:
- 文献综述综合当前知识.
- 临床前期和早期临床研究的分析.
- 专注于机械洞察力和翻译障碍.
主要成果:
- 微生物群动态调节宿主免疫力,影响免疫治疗反应.
- 微生物组失调可以导致irAEs,使治疗复杂化.
- 精密微生物干预显示了增强免疫疗法的潜力.
结论:
- 整合微生物组数据可以个性化癌症免疫疗法.
- 需要进一步的多中心试验来验证微生物干预措施.
- 微生物组是提高癌症治疗有效性和安全性的关键目标.
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